Monoamine Transporter

Cat. No.

A67402

CAS No.

3038464-68-2

NMDAR antagonist 5

NMDAR antagonist 5 (Compound A17) is a selective antagonist targeting the N-methyl-D-aspartate receptor (NMDAR) with an IC50 of 0.3 µM. This compound also inhibits monoamine transporters, including the serotonin transporter (SERT, IC50 = 1.1 µM), dopamine transporter (DAT, IC50 = 0.7 µM), and norepinephrine transporter (NET, IC50 = 2.7 µM). With a favorable safety profile and low toxicity across multiple organ systems, NMDAR antagonist 5 demonstrates potential antidepressant effects, making it a valuable tool for research into depression and related neurological disorders.

Cat. No.

A79115

CAS No.

171655-91-7

Brasofensine

Synonyms: BMS-204756

Brasofensine is a potent oral-active dopamine transporter antagonist. Its primary mechanism involves blocking the reuptake of monoamines, which enhances dopaminergic signaling. This compound is primarily utilized in research related to Parkinson's disease, contributing to studies focused on dopaminergic dysfunction and potential therapeutic strategies.