We use analytics and advertising cookies, which you can accept or reject; see our privacy policy.

Current choice:

TRP Channel

Transient receptor potential (TRP) channel modulators act on cation channels that sense heat, cold and irritants. The mammalian family has six subfamilies, including vanilloid (TRPV), ankyrin (TRPA), canonical (TRPC) and melastatin (TRPM) channels. TRP channels respond to temperature, touch, osmotic changes and plant-derived compounds, so they are often described as cellular sensors. Cloning of the capsaicin receptor TRPV1 in 1997 identified it as a heat-activated ion channel in pain-sensing neurons. AMG517 and SB-705498 are TRPV1 antagonists, while A 967079 blocks TRPA1 and optovin activates TRPA1 when exposed to light. Pyr10 inhibits TRPC3, and Pico145 inhibits channels formed by TRPC1, TRPC4 and TRPC5. The spider toxin peptide GsMTx4, an inhibitor of mechanosensitive channels, is also listed under Piezo Channel.

2 Items

  • Ricorfotide vedotin
    Cat. No.
    A53640
    CAS No.
    2082631-84-1

    Ricorfotide vedotin

    Synonyms: CBP-1008; LDC 10B

    Ricorfotide vedotin is a dual-ligand peptide-drug conjugate that primarily targets Folate receptor α (FRα) while also binding to TRPV6. It exhibits high-affinity binding to FRα and low-affinity interaction with TRPV6, demonstrating notable antitumor activity. This reagent is applicable in advanced solid tumor research, including studies focused on colorectal cancer, breast cancer, non-small cell lung cancer, ovarian cancer, adrenocortical carcinoma, and follicular dendritic cell sarcoma.

    In stock View Details
    1 mg
    $320.00
    5 mg
    $820.00
    All 4 sizes
  • KJM429
    Cat. No.
    A68827
    CAS No.
    401907-57-1

    KJM429

    Synonyms: MK-056

    KJM429 is a high-affinity ligand targeting the rat vanilloid receptor rTRPV1, exhibiting a Ki value of 30-63 nM. This compound functions as a competitive antagonist to inhibit TRPV1 activation by stimuli such as capsaicin, resiniferatoxin, and thermal signals, while switching to an agonist role under acidic conditions (pH < 5.5). KJM429 effectively modulates calcium influx associated with TRPV1 activation, making it a valuable tool for investigating the mechanisms underlying pain-related disorders, including postherpetic neuralgia, diabetic neuropathy, cluster headache, osteoarthritis, and pruritus.

    In stock View Details
    25 mg
    $1,275.00
    50 mg
    $1,625.00
    All 3 sizes

2 Items

Added to your cart

View Cart Checkout

    Loading...