PHA-848125 (Milciclib)

Catalog No.: A11047

CDK Inhibitor

PHA-848125 (Milciclib)

PHA-848125 (Milciclib) Chemical Structure

CAS NO. 802539-81-7

PHA-848125 (Milciclib) is an orally bioavailable inhibitor of CDKs and TRKA with potential antineoplastic activity.

Availability: Out of stock

Package Price
5 mg
$200.00
10 mg
$320.00
50 mg
$850.00
100 mg
$1,650.00
10mM * 1mL in DMSO
$243.00
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Biological Activity

PHA-848125 (Milciclib) is an orally bioavailable inhibitor of CDKs and TRKA with potential antineoplastic activity.
Targets
Target Value
CDK2/CyclinAIC50: 45nM
TrkAIC50: 53nM
CDK7/CyclinHIC50: 150nM
CDK4/CyclinD1IC50: 160nM
CDK5/p35IC50: 265nM
CDK2/CyclinEIC50: 363nM
CDK1/CyclinBIC50: 398nM
In vitro (25°C) DMSO 92 mg/mL (199.75 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.71 mL 108.55 mL 217.11 mL
0.5 mM 4.34 mL 21.71 mL 43.42 mL
1 mM 2.17 mL 10.86 mL 21.71 mL
5 mM 0.43 mL 2.17 mL 4.34 mL

*The above data is based on the productmolecular weight 460.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11047
Actions Inhibitor
M. Wt 460.6
Formula C25H32N8O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 802539-81-7
Synonyms Milciclib, PHA848125
SMILES CC1(CC2=CN=C(N=C2C3=C1C(=NN3C)C(=O)NC)NC4=CC=C(C=C4)N5CCN(CC5)C)C

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