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PHA-848125 (Milciclib)

Catalog No.: A11047

CDK Inhibitor

PHA-848125 (Milciclib)

PHA-848125 (Milciclib) Chemical Structure

CAS NO. 802539-81-7

PHA-848125 (Milciclib) is an orally bioavailable inhibitor of CDKs and TRKA with potential antineoplastic activity.

Availability: Out of stock

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5 mg

Regular Price: $200.00

Special Price $160.00

10 mg

Regular Price: $320.00

Special Price $256.00

50 mg

Regular Price: $850.00

Special Price $680.00

100 mg

Regular Price: $1,650.00

Special Price $1,320.00

10mM * 1mL in DMSO

Regular Price: $243.00

Special Price $194.40

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

PHA-848125 (Milciclib) is an orally bioavailable inhibitor of CDKs and TRKA with potential antineoplastic activity.
Target Value
CDK2/CyclinAIC50: 45nM
TrkAIC50: 53nM
CDK7/CyclinHIC50: 150nM
CDK4/CyclinD1IC50: 160nM
CDK5/p35IC50: 265nM
CDK2/CyclinEIC50: 363nM
CDK1/CyclinBIC50: 398nM
In vitro (25°C) DMSO 91 mg/mL (197.58 mM)
Water Insoluble
Ethanol Insoluble
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.71 mL 108.55 mL 217.11 mL
0.5 mM 4.34 mL 21.71 mL 43.42 mL
1 mM 2.17 mL 10.86 mL 21.71 mL
5 mM 0.43 mL 2.17 mL 4.34 mL

*The above data is based on the productmolecular weight 460.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11047
Actions Inhibitor
CAS No. 802539-81-7
Formula C25H32N8O
M. Wt 460.6
Purity >98%
Synonyms Milciclib, PHA848125

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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