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Publications citing Adooq Products
Chemical Information
| Catalog Num | A11047 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 460.6 |
| Formula | C25H32N8O |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 802539-81-7 |
| Synonyms | Milciclib, PHA848125 |
| SMILES code | CC1(CC2=CN=C(N=C2C3=C1C(=NN3C)C(=O)NC)NC4=CC=C(C=C4)N5CCN(CC5)C)C |
| Chemical Name | N,1,4,4-tetramethyl-8-((4-(4-methylpiperazin-1-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide |
Description |
PHA-848125 (Milciclib) is an orally bioavailable inhibitor of CDKs and TRKA with potential antineoplastic activity. | ||||||||||||||||
Targets |
|
||||||||||||||||
| Solubility (25°C) * | In vitro | DMSO | 92 mg/mL (199.75 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 30% propylene glycol, 5% Tween 80, 65% D5W | 30 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.71 mL | 108.55 mL | 217.11mL |
| 0.5 mM | 4.34 mL | 21.71 mL | 43.42 mL |
| 1 mM | 2.17 mL | 10.86 mL | 21.71 mL |
| 5 mM | 0.43 mL | 2.17 mL | 4.34 mL |
*The above data is based on the productmolecular weight 460.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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