UNC8153 is a potent and selective degrader targeting nuclear receptor-binding SET domain-containing protein 2 (NSD2), with a binding affinity (Kd) of 24 nM. It induces proteasome-dependent degradation of NSD2 by incorporating a simple warhead, leading to a reduction in both NSD2 protein levels and the associated H3K36me2 chromatin mark in cells. UNC8153 is a valuable chemical tool for investigating NSD2 function and epigenetic regulation.
UNC8153 is a potent and selective degrader targeting nuclear receptor-binding SET domain-containing protein 2 (NSD2), with a binding affinity (Kd) of 24 nM. It induces proteasome-dependent degradation of NSD2 by incorporating a simple warhead, leading to a reduction in both NSD2 protein levels and the associated H3K36me2 chromatin mark in cells. UNC8153 is a valuable chemical tool for investigating NSD2 function and epigenetic regulation.
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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