YM458

Name: YM458
Brand: Adooq Bioscience
SKU: A24415
Rating: 5 (288 reviews)

Catalog No.: A24415

EZH2/BRD4 inhibitor

YM458 is a potent dual inhibitor of EZH2 and BRD4, with IC₅₀ values of 490 nM and 34 nM, respectively. It suppresses cell proliferation and colony formation, and induces cell cycle arrest and apoptosis in solid tumor cells. YM458 is suitable for anticancer research.

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Grouped product items
Size	Price	Stock
1mg	$765.00	In stock
5mg	$2,295.00	In stock
10mg	$3,910.00	In stock
50mg	$11,730.00	In stock
Bulk Size	Bulk Discount

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Biological Activity

Description	YM458 is a potent dual inhibitor of EZH2 and BRD4, with IC₅₀ values of 490 nM and 34 nM, respectively. It suppresses cell proliferation and colony formation, and induces cell cycle arrest and apoptosis in solid tumor cells. YM458 is suitable for anticancer research.

Product Information

Catalog Num	A24415
Formula	C53H61ClN8O5S
Molecular Weight	957.62
CAS Number	2770108-93-3
SMILES	CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@@H](CC(NCCCCCOC4=CC=C(C5=CC(N(C6CCOCC6)CC)=C(C(C(NCC7=C(C=C(NC7=O)C)C)=O)=C5)C)C=C4)=O)C8=NN=C(C)N28
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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