SB590885

B-Raf Inhibitor

158 Customer Reviews
Catalog No. A10829

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
SB590885 5mg A10829-5
$90.00
SB590885 10mg A10829-10
$136.00
SB590885 50mg A10829-50
$450.00
SB590885 100mg A10829-100
$750.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

SB590885 is a selective small-molecule inhibitor of the B-Raf kinase and Ki app values are 0.16 and 1.72 nM for B-Raf and c-Raf respectively.

SB590885

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Chemical Information

Catalog Num A10829
Actions Inhibitor
M. Wt 453.5
Formula C27H27N5O2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 405554-55-4
Synonyms SB-590885
SMILES code CN(C)CCOC1=CC=C(C=C1)C2=N/C(=C\3/C=CC4=C(CCC4=C3)N=O)/C(=C5C=CNC=C5)N2
Chemical Name 5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime

Biological Activity

Description
SB590885 is a selective small-molecule inhibitor of the B-Raf kinase and Ki app values are 0.16 and 1.72 nM for B-Raf and c-Raf respectively.
Targets
B-Raf (Cell-free assay)
0.16 nM(Ki)

Solubility

Solubility (25°C) * In vitro DMSO 5 mg/mL (11.02 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 2% Cremophor EL, 2% N,N-dimethylacetamide, pH 5.0 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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