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Leukotriene Receptor

Leukotriene receptor antagonists block the G protein-coupled receptors for cysteinyl leukotrienes and leukotriene B4. The cysteinyl leukotrienes C4, D4 and E4 (LTC4, LTD4, LTE4) derive from arachidonic acid through 5-lipoxygenase. They act mainly on cysteinyl leukotriene receptor 1 (CysLT1), which mediates airway smooth muscle contraction. Leukotriene B4 (LTB4) signals through leukotriene B4 receptor 1 (BLT1), a separate receptor that mediates leukocyte chemotaxis. CysLT1 antagonists in this category include montelukast sodium, zafirlukast, pranlukast and MK-571. Amelubant blocks LTB4 receptors and serves as a tool for studies of neutrophil recruitment.

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  • H-Ala-pNA
    Cat. No.
    A61102
    CAS No.
    1668-13-9

    H-Ala-pNA

    H-Ala-pNA is a specific substrate for leukotriene A4 hydrolase, consisting of an L-amino acid p-nitroaniline derivative. Upon catalytic hydrolysis by leukotriene A4 hydrolase, H-Ala-pNA generates p-nitroaniline, which can be quantitatively monitored at 405 nm, facilitating the assessment of enzyme activity. This compound is essential for evaluating the effectiveness of inhibitors that target the amidase function of leukotriene A4 hydrolase, contributing to research on inflammatory processes and related diseases.

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