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Platelet-Activating Factor (PAF) Receptors

Platelet-activating factor (PAF) receptor antagonists block a G protein-coupled receptor for an inflammatory lipid. PAF is released by platelets, leukocytes and endothelial cells and promotes platelet aggregation, leukocyte activation and vascular permeability. The PAF receptor was cloned by functional expression from guinea pig lung in 1991. Ginkgolide B and ginkgolide A are terpene lactones from Ginkgo biloba that serve as classic natural PAF receptor antagonists. Foropafant, tulopafant and 48740 RP are synthetic antagonists developed for the same receptor. Rupatadine fumarate also blocks the histamine H1 receptor, and CP-96486 also blocks the leukotriene D4 (LTD4) receptor. Further ligands of these receptors are found under Histamine Receptors and Leukotriene Receptor.

1 Item

  • Lyso-PAF C-16
    Cat. No.
    A77109
    CAS No.
    52691-62-0

    Lyso-PAF C-16

    Lyso-PAF C-16 is a key precursor and metabolite of 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (PAF C-16). It serves as a substrate in the remodeling pathway for the formation of PAF C-16 and is also involved in the selective acylation with arachidonic acid through a CoA-independent transacylase. This compound is beneficial for research into lipid metabolism and the roles of bioactive lipids in various biological processes.

    In stock View Details
    1 mg
    $45.00
    5 mg
    $125.00
    All 2 sizes

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