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5-HT Receptors

5-HT receptor agonists and antagonists act on receptors for serotonin, also called 5-hydroxytryptamine (5-HT). Serotonin receptors are classified into seven families, 5-HT1 to 5-HT7, and most of them are G protein-coupled receptors. The 5-HT3 receptor is the exception, a serotonin-gated ion channel whose structure was reported in 1991. These receptors regulate mood, sleep, appetite, vascular tone and gut motility, so they are studied across neuroscience and physiology. Ligands in this category include WAY-100635, a 5-HT1A antagonist, and eletriptan hydrobromide, a 5-HT1B/1D agonist. Prucalopride, an agonist at the 5-HT4 receptor, is also listed.

1 Item

  • 5-PT
    Cat. No.
    A95212
    CAS No.
    92085-05-7

    5-PT

    Synonyms: 5-Propargyltryptamide

    5-Propargyltryptamide (5-PT) is an alkyne-functionalized derivative of serotonin (5-HT), serving as a substrate for serotonylation in living cells. This reagent enables the conjugation of biotin, facilitating the identification of serotonylated proteins through copper-catalyzed click chemistry and mass spectrometry. 5-PT selectively labels and isolates serotonylated proteins in alveolar epithelial cells, making it a valuable tool for proteomic analysis in the study of bronchopulmonary dysplasia and related respiratory conditions.

    In stock View Details
    1 mg
    $155.00
    5 mg
    $395.00
    All 7 sizes

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