Ampyrone-d3 is a deuterium-labeled derivative of Ampyrone, a reversible and low-damage optical clearing agent that acts as a non-selective inhibitor of cyclooxygenase (COX). It enhances optical transmittance in mouse skin and other tissues by inducing tissue refractive index matching through improved UV absorption, thereby facilitating tissue transparency in vivo. Additionally, Ampyrone-d3 exhibits anti-inflammatory, analgesic, and antipyretic activities by inhibiting the synthesis of prostaglandin PGE2 and is involved in mitigating DNA damage, apoptosis, and immune cell phagocytosis during chemotherapy with agents such as Doxorubicin and Cisplatin. This compound is valuable for research in optical imaging and cancer therapeutics.
Ampyrone-d3 is a deuterium-labeled derivative of Ampyrone, a reversible and low-damage optical clearing agent that acts as a non-selective inhibitor of cyclooxygenase (COX). It enhances optical transmittance in mouse skin and other tissues by inducing tissue refractive index matching through improved UV absorption, thereby facilitating tissue transparency in vivo. Additionally, Ampyrone-d3 exhibits anti-inflammatory, analgesic, and antipyretic activities by inhibiting the synthesis of prostaglandin PGE2 and is involved in mitigating DNA damage, apoptosis, and immune cell phagocytosis during chemotherapy with agents such as Doxorubicin and Cisplatin. This compound is valuable for research in optical imaging and cancer therapeutics.
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