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Activating transcription factor 6 (ATF6) participates in the cellular response to endoplasmic reticulum stress. This membrane-associated sensor undergoes processing that releases a transcriptional regulator, linking protein folding conditions to changes in gene expression. Ceapin-A7 is listed as an ATF6 alpha inhibitor, while AA147 is a regulator of endoplasmic reticulum protein homeostasis associated with ATF6 signaling. The category groups these distinct research compounds for examining the unfolded protein response and the organization of cellular protein maintenance.
AA147, a small molecule endoplasmic reticulum (ER) proteostasis regulator, selectively activates ATF6 arm of the unfolded protein response (UPR) extracted from patent WO2017117430A1, compound 147*.
Ceapin-A7 is a selective blocker of ATF6α signaling in response to ER stress, with an IC50 of 0.59 μM.
