Azaribine, a potent inhibitor of orotidine monophosphate decarboxylase (OMPD), serves as an effective antiviral agent against several RNA viruses. It disrupts viral genome replication and gene transcription, demonstrating broad-spectrum antiviral activity with EC50 values ranging from 3.80 nM to 1.73 μM against influenza A and B viruses, and an EC50 of 1.62 μM against Zika virus (ZIKV Paraiba). Additionally, Azaribine holds potential for research applications related to psoriasis.
Azaribine, a potent inhibitor of orotidine monophosphate decarboxylase (OMPD), serves as an effective antiviral agent against several RNA viruses. It disrupts viral genome replication and gene transcription, demonstrating broad-spectrum antiviral activity with EC50 values ranging from 3.80 nM to 1.73 μM against influenza A and B viruses, and an EC50 of 1.62 μM against Zika virus (ZIKV Paraiba). Additionally, Azaribine holds potential for research applications related to psoriasis.
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