Assay Controls & Cell Stimulation

Cat. No.

A15865

CAS No.

1219810-16-8

RSL3

Synonyms: 1S,3R-RSL3

RSL3 is a ferroptosis activator in a VDAC-independent manner,exhibiting selectivity for tumor cells bearing oncogenic RAS.

Cat. No.

A16445

CAS No.

50-63-5

Chloroquine Phosphate

Chloroquine phosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator.

Cat. No.

A14616

CAS No.

16561-29-8

12-O-tetradecanoyl phorbol-13-acetate

Synonyms: TPA; Phorbol 12-myristate 13-acetate

12-O-tetradecanoyl phorbol-13-acetate is a diester of phorbol and is a tumor promoting compound extracted from croton oil. It is a reversible, highly potent protein kinase C (PKC) activator in vitro and in vivo at nM concentrations.

Cat. No.

A20681

CAS No.

28643-80-3

Nigericin sodium salt

Synonyms: Sodium Nigericin

Nigericin sodium salt is an antibiotic from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore, a NLRP3 activator.

Cat. No.

A24102

CAS No.

28380-24-7

Nigericin

Nigericin is an antibiotic derived from Streptomyces hygroscopicus that act as a K+/H+ ionophore, promoting K+/H+ exchange across mitochondrial membranes. Nigericin is a NLRP3 activator. Nigericin shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin induces pyroptosis through caspase 1/GSDMD in TNBC.

Cat. No.

A27071

CAS No.

1538593-71-3

Piperazine Erastin

Piperazine Erastin is a ferroptosis inducer that triggers an iron-dependent form of non-apoptotic cell death. This compound is instrumental in cancer research, providing valuable insights into the mechanisms of ferroptosis and potential therapeutic applications in oncology. Its unique action offers a powerful tool for studying cellular metabolism and death pathways in various cancer models.

Cat. No.

A33158

CAS No.

11089-65-9

Tunicamycin

Tunicamycin is an ER stress inducer that inhibits N-linked glycosylation by blocking GlcNAc phosphotransferase (GPT). This action leads to the accumulation of unfolded proteins within the endoplasmic reticulum, resulting in ER stress, DNA synthesis inhibition, and G1 phase cell cycle arrest. Additionally, Tunicamycin exhibits antimicrobial activity against gram-positive bacteria, yeasts, fungi, and viruses while demonstrating anti-cancer potential. Notably, it also enhances exosome release in cervical cancer cells, making it valuable for research in cancer biology and cellular stress response pathways.