CTLA-4, LAG-3, TIGIT & Other Checkpoints

Cat. No.

AT1286

M6903

M6903 is a humanized monoclonal IgG2 antibody that specifically targets T cell immunoglobulin and mucin domain-3 (TIM-3), exhibiting a dissociation constant (K_D) of 2.3 nM for human TIM-3. This antibody effectively binds to TIM-3, inhibiting its interaction with key ligands including phosphatidylserine (PtdSer), carcinoembryonic antigen cell adhesion-related molecule 1 (CEACAM1), and galectin 9 (Gal-9). By blocking these interactions, M6903 mitigates TIM-3-mediated suppression of T cell activity, thereby activating antigen-specific T cells and enhancing anti-tumor immune responses. This antibody is particularly valuable for research focused on cancer immunology and the development of immunotherapeutic strategies.

Cat. No.

AT1353

CAS No.

2750031-18-4

Muzastotug

Muzastotug is a humanized immunoglobulin G1-kappa monoclonal antibody targeting CTLA-4 (Cytotoxic T-Lymphocyte-Associated Protein 4). It functions as both an immunostimulant and an antineoplastic agent. This antibody is designed to enhance the immune system's response against tumor cells by inhibiting CTLA-4, a protein that downregulates the immune response.

Cat. No.

AT1389

CAS No.

2760549-50-4

Vilastobart

Vilastobart is a human IgG1 κ monoclonal antibody targeting CTLA-4. For accurate experimental control, it is recommended to use Human IgG1 kappa as an isotype control.

Cat. No.

AT1417

CAS No.

2649371-19-5

Sovipostobart

Sovipostobart is a human monoclonal antibody of the immunoglobulin G1-kappa class, specifically targeting CTLA-4 with a cleavable prodomain. It functions as both an immunostimulant and an antineoplastic agent. This biologic is designed to modulate the immune system by inhibiting CTLA-4, a protein that downregulates immune responses, thereby enhancing the body's antitumor activity. Sovipostobart is applicable in the study of immune checkpoint blockade therapies and is relevant for research focused on cancer immunotherapy.

Cat. No.

AT1429

GSK-4381562

Anti-PVRIG (GSK4381562) is a human monoclonal antibody of the immunoglobulin G1 (IgG1) class, targeting the poliovirus receptor-related immunoglobulin domain-containing protein (PVRIG, also known as CD112R). This antibody is designed to modulate immune response through its inhibitory effects on the PVRIG pathway, which is implicated in immune checkpoint regulation. The interaction between Anti-PVRIG and its target has the potential to enhance antitumor immune activity by alleviating immune suppression in the tumor microenvironment, thereby offering therapeutic benefits in oncology research and treatment.

Cat. No.

AT1456

CAS No.

2407760-40-9

Volrustomig

Synonyms: MEDI-5752

Volrustomig is a human IgG1 κ monoclonal antibody targeting CTLA4 and PDCD1. For accurate experimental control, it is recommended to use Human IgG1 kappa Isotype Control.

Cat. No.

AT1478

CAS No.

2236068-83-8

Icatolimab

Icatolimab is a humanized antibody derived from Chinese Hamster Ovary (CHO) cells, specifically designed to target BTLA/CD272. This antibody is comprised of human IgG4SP type heavy chains and human kappa type light chains, exhibiting a predicted molecular weight of 146 kDa. For experimental controls, the corresponding isotype control recommended is Human IgG4 kappa.

Cat. No.

AT1509

CAS No.

2408310-37-0

Botensilimab

Synonyms: AGEN 1181

Botensilimab (AGEN 1181) is a human monoclonal antibody that targets cytotoxic T-lymphocyte antigen 4 (CTLA-4), serving as both an innate and adaptive immune activator. This biologic is specifically designed for use in cancer research, where it facilitates the study of immune checkpoint blockade and its effects on tumor immunity.

Cat. No.

AT1515

CAS No.

2935496-38-9

TTX-030

Synonyms: Eltivutabart

TTX-030 is a humanized monoclonal antibody produced in Chinese Hamster Ovary (CHO) cells, specifically targeting ENTPD1/CD39. This antibody is comprised of a human IgG4SP heavy chain and a human kappa light chain, exhibiting a predicted molecular weight of 150 kDa. For isotype control purposes, Human IgG4 kappa, Isotype Control is recommended. TTX-030 is designed for the detailed study of CD39 activity and its role in immunoregulation, making it an essential tool for research in immunology and cancer biology.