Cytokines, Chemokines & Receptors

Cat. No.

AT0323

CAS No.

2376858-66-9

Tozorakimab

Synonyms: MEDI-3506

Tozorakimab (MEDI-3506) is a human immunoglobulin G1 (IgG1) monoclonal antibody designed to specifically target interleukin-33 (IL-33). This antibody plays a critical role in modulating immune responses by reducing inflammation and epithelial dysfunction. Tozorakimab is primarily utilized in research focused on chronic obstructive pulmonary disease (COPD), providing a valuable tool for exploring the pathophysiology and potential therapeutic interventions for this condition.

Cat. No.

AT0324

Anti-CCR8 Antibody (10A11)

Anti-CCR8 Antibody (10A11) is a humanized IgG1 monoclonal antibody specifically designed to target CCR8, a chemokine receptor implicated in various inflammatory and immune processes. This antibody is recommended for use with Human IgG1 kappa as an isotype control to ensure specificity and accuracy in experimental applications.

Cat. No.

AT0327

Anti-IL-20Ra Antibody

Cat. No.

AT0330

CAT-2200

CAT-2200 is a humanized monoclonal antibody produced in Chinese Hamster Ovary (CHO) cells, specifically targeting CTLA-8/IL-17A. This antibody is constructed with a human IgG1 heavy chain and a human lambda light chain, exhibiting a predicted molecular weight of 145 kDa. For isotype control purposes, Human IgG1 kappa, Isotype Control is recommended. CAT-2200 serves as a valuable tool in the study of immune responses related to IL-17A, offering potential applications in immunological research and therapeutic development.

Cat. No.

AT0333

CAS No.

1638332-55-4

Otilimab

Synonyms: GSK 3196165; MOR103

Otilimab (GSK 3196165) is a human monoclonal antibody targeting the granulocyte-macrophage colony-stimulating factor (GM-CSF). This antibody effectively neutralizes GM-CSF by inhibiting its interaction with the cell surface receptor, thereby modulating the biological activities mediated by this cytokine. Otilimab is primarily researched for its potential therapeutic applications in conditions where GM-CSF plays a key role in pathogenesis.

Cat. No.

AT0335

Anti-CSF2/GM-CSF Antibody

The Anti-CSF2/GM-CSF Antibody is a recombinant human monoclonal antibody produced in Chinese Hamster Ovary (CHO) cells. It specifically targets the cytokine CSF2, also known as granulocyte-macrophage colony-stimulating factor (GM-CSF), playing a crucial role in immune system regulation by stimulating the production of white blood cells. This antibody is comprised of a human IgG1-type heavy chain and a human lambda-type light chain, with a predicted molecular weight of 145.02 kDa. For experimental controls, it is recommended to use Human IgG1 kappa, Isotype Control, which serves as an appropriate isotype control for this antibody. This product is essential for research focused on immunology, inflammation, and potential therapeutic interventions involving GM-CSF.

Cat. No.

AT0345

CAS No.

946414-98-8

Eldelumab

Synonyms: BMS-936557; MDX-1100

Eldelumab (BMS-936557) is a human monoclonal antibody of the IgG1 subtype designed to selectively target and neutralize CXCL10 (IP-10). By binding to CXCL10, Eldelumab effectively inhibits CXCL10-induced calcium flux and cellular migration. This antibody is particularly useful in research focused on autoimmune and auto-inflammatory disorders, including rheumatoid arthritis, ulcerative colitis, and Crohn's disease, providing a valuable tool for elucidating the role of CXCL10 in these conditions.

Cat. No.

AT0356

Anti-CXCR3/GPR9/CD183 Antibody

The Anti-CXCR3/GPR9/CD183 Antibody is derived from human sources and expressed in Chinese Hamster Ovary (CHO) cells. This antibody specifically targets the CXCR3/GPR9/CD183 receptor, which is implicated in various immunological responses. Featuring a human IgG1 heavy chain and a human kappa light chain, this antibody has a predicted molecular weight of 150 kDa. For isotype control purposes, reference is made to the Human IgG1 kappa, Isotype Control, ensuring accurate and reliable experimental results.

Cat. No.

AT0365

Anti-IFNAR1 Antibody

The Anti-IFNAR1 Antibody is a humanized monoclonal antibody produced in Chinese Hamster Ovary (CHO) cells, specifically targeting the Interferon alpha/beta receptor 1 (IFNAR1). This antibody comprises a human IgG1 heavy chain and a human kappa light chain, with a predicted molecular weight of 144.92 kDa. For isotype control, Human IgG1 kappa, Isotype Control is recommended. This product is essential for research focusing on the signaling pathways and immunological responses mediated by IFNAR1.

Cat. No.

AT0384

CAS No.

2043952-59-4

Abrezekimab

Synonyms: UCB4144; VR 942

Abrezekimab (VR 942), featuring CDP7766, is a humanized, high-affinity monoclonal antibody fragment with neutralizing properties against human interleukin-13 (IL-13). It specifically binds to IL-13, effectively preventing interaction with the IL-13Rα1 receptor subunit. This antibody is primarily utilized in asthma research to investigate the role and therapeutic potential of IL-13 inhibition in disease pathogenesis and progression.

Cat. No.

AT0390

CAS No.

2856372-57-9

Indemakitug

Indemakitug is a human monoclonal antibody of the IgG1λ2 subtype that specifically targets interferon-gamma (IFNG). For experimental control purposes, it is recommended to use Human IgG1 lambda2 as an isotype control.

Cat. No.

AT0394

CAS No.

953400-68-5

Lebrikizumab

Synonyms: TNX-650

Lebrikizumab (TNX-650) is a humanized IgG4 monoclonal antibody that targets interleukin-13 (IL-13), binding specifically to a non-receptor binding domain of IL-13 to inhibit its activity. This antibody effectively blocks the IL-13-driven Th2 inflammatory response by interfering with the signaling pathway involving IL-4Rα/IL-13Rα1. Lebrikizumab also exhibits anti-itch properties, making it a valuable tool for research into asthma, atopic dermatitis, and neuroinflammatory disorders.

Cat. No.

AT0400

CAS No.

1007106-86-6

Fezakinumab

Synonyms: ILV 094

Fezakinumab is a monoclonal antibody targeting interleukin-22 (IL-22), designed for the investigation of inflammatory conditions including psoriasis and rheumatoid arthritis. This antibody binds specifically to IL-22, a cytokine involved in the regulation of inflammatory responses, offering a valuable tool for researchers studying the pathophysiology and potential therapeutic interventions for these diseases.

Cat. No.

AT0411

CAS No.

142864-19-5

Enlimomab

Synonyms: BI-RR 0001; Anti-Human IL6 Recombinant Antibody

Enlimomab (BI-RR 0001) is a murine IgG2a monoclonal antibody that targets human Intercellular Adhesion Molecule 1 (ICAM-1). This antibody functions by inhibiting leukocyte adhesion to vascular endothelium, effectively reducing leukocyte extravasation and subsequent inflammatory tissue damage. Due to its anti-inflammatory properties, Enlimomab is particularly useful in research focused on stroke and related inflammatory processes.

Cat. No.

AT0419

CAS No.

2648260-80-2

Rademikibart

Synonyms: CBP-201

Rademikibart (CBP-201) is a human monoclonal antibody specifically designed to target IL-4Rα, exhibiting a high binding affinity with a dissociation constant (K_D) of 20.7 pM for human IL-4Rα epitopes. This antibody is characterized by its species specificity, as it does not interact with IL-4Rα from non-human species. Rademikibart effectively inhibits both IL-4 and IL-13-mediated STAT6 signaling pathways, as well as TF-1 cell proliferation and TARC production in peripheral blood mononuclear cells (PBMCs). This antibody is particularly relevant for research into moderate-to-severe Th2-mediated inflammatory diseases, providing a valuable tool for elucidating disease mechanisms and potential therapeutic targets.

Cat. No.

AT0421

CAS No.

2492472-82-7

Camoteskimab

Synonyms: AVTX-007; CERC-007; MEDI 2338

Camoteskimab (AVTX-007) is a fully humanized, high-affinity monoclonal antibody targeting interleukin-18 (IL-18). By specifically binding to IL-18, Camoteskimab effectively inhibits the interaction between IL-18 and its receptor, thereby modulating the inflammatory response. This antibody is particularly valuable in research focused on cardiovascular and autoinflammatory diseases, including adult-onset Still’s disease (AOSD) and multiple myeloma, providing a potent tool for investigating the pathological roles of IL-18 in these conditions.

Cat. No.

AT0426

GSK-2330811

GSK-2330811 is a humanized IgG1 monoclonal antibody specifically designed to target Oncostatin M (OSM). This antibody is primarily utilized in research focused on diffuse cutaneous systemic sclerosis (dcSSc). For experimental control purposes, Human IgG1 kappa serves as the appropriate isotype control for GSK-2330811.

Cat. No.

AT0427

CAS No.

2084037-83-0

Quetmolimab

Quetmolimab is a humanized monoclonal antibody targeting CX3CL1, a chemokine known for its role in modulating chemotaxis and cell adhesion. This antibody is designed for precision in binding and neutralizing CX3CL1, making it a valuable tool for research into inflammatory responses and immune cell migration.

Cat. No.

AT0432

CAS No.

2893793-17-2

Crebankitug

Crebankitug is a human monoclonal antibody of the IgG1λ2 subtype that specifically targets the IL7 receptor (IL7R). For experimental control purposes, it is recommended to use Human IgG1 lambda2 as an isotype control. This antibody is designed for use in research studies to investigate IL7R-mediated signaling pathways and potential therapeutic applications targeting IL7R.

Cat. No.

AT0441

CAS No.

2368950-15-4

Ponsegromab

Synonyms: PF 06946860

Ponsegromab (PF 06946860) is a potent, selective humanized monoclonal antibody targeting GDF15, designed to inhibit its interaction with the GFRAL receptor. By binding to GDF15, Ponsegromab effectively prevents GDF15 from engaging with the GFRAL receptor, thereby obstructing the GDF15/GFRAL-mediated signaling pathway. This antibody exhibits significant anti-cachexia activity, making it a valuable tool for research in oncology settings where cachexia is prevalent.

Cat. No.

AT0446

Anti-TNFSF2/TNFa Antibody

The Anti-TNFSF2/TNFa Antibody is a recombinant human monoclonal antibody produced in Chinese Hamster Ovary (CHO) cells. It specifically targets TNFSF2/TNFa, a pivotal cytokine involved in systemic inflammation and the acute phase response. This antibody is composed of a human IgG1 heavy chain and a human kappa light chain, with an approximate molecular weight of 145 kDa. For experimental control purposes, it is recommended to use the Human IgG1 kappa, Isotype Control. This antibody is suitable for a range of research applications, providing a critical tool for the study of TNF-alpha's role in disease pathogenesis and therapeutic interventions.

Cat. No.

AT0449

CAS No.

1528523-94-5

Dectrekumab

Synonyms: QAX576

Dectrekumab (QAX576) is a human monoclonal antibody designed to selectively target interleukin-13 (IL-13). This antibody has demonstrated efficacy in significantly reducing intraepithelial esophageal eosinophil counts and normalizing dysregulated disease-related transcripts in patients with Eosinophilic Esophagitis (EoE). Its sustained activity makes it an invaluable tool for research focused on inflammation and immunological disorders.

Cat. No.

AT0463

Anti-IL-20 Antibody

The Anti-IL-20 Antibody is a humanized monoclonal antibody produced in Chinese hamster ovary (CHO) cells, specifically designed to target IL-20. This antibody consists of a human IgG1 type heavy chain and a human kappa type light chain, with an approximate molecular weight of 150 kDa. For experimental control purposes, Human IgG1 kappa, Isotype Control is recommended.

Cat. No.

AT0470

CAS No.

2639474-65-8

Dazukibart

Dazukibart is a humanized IgG1κ monoclonal antibody derived from mouse sources, specifically designed to target Interferon beta 1 (IFNB1). This antibody is engineered to bind selectively to IFNB1, making it an essential tool for research focused on the role of this cytokine in immune response and inflammatory processes. Dazukibart is suitable for a variety of experimental applications, including functional assays and immunological studies aimed at elucidating the biological pathways mediated by IFNB1.

Cat. No.

AT0485

CAS No.

2231258-73-2

Adakitug

Synonyms: BMS-986253; HuMax-IL-8

Adakitug (BMS-986253) is a recombinant human monoclonal antibody expressed in Chinese Hamster Ovary (CHO) cells, specifically designed to target CXCL8/IL-8. This antibody is comprised of a human IgG1 heavy chain and a human kappa light chain, with a predicted molecular weight of 144.94 kDa. For experimental control purposes, Human IgG1 kappa, Isotype Control is recommended.