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Other Targets lists biosimilar antibodies whose targets fall outside the main groups or have few products. Examples include omalizumab and ligelizumab, which bind immunoglobulin E (IgE), and bimagrumab, which blocks activin type II receptors. Lirilumab targets killer-cell immunoglobulin-like receptors (KIRs) on natural killer cells. The group also includes antibodies to allergens, Wnt pathway receptors, proteases, transporters and intracellular proteins such as histones. Several fusion proteins and peptide conjugates are listed here as well, including the long-acting granulocyte colony-stimulating factor (G-CSF) analogs balugrastim and eflapegrastim.
GBR-900 is a humanized monoclonal antibody produced in Chinese Hamster Ovary (CHO) cells, specifically designed to target the TrkA/NTRK1 receptor. This antibody is comprised of a human IgG1 heavy chain and a human kappa light chain, with an estimated molecular weight of 150 kDa. For experimental control purposes, Human IgG1 kappa, Isotype Control is recommended.
Synonyms: SARS-80R; SARS Antibody-80R
The Anti-SARS-80R monoclonal antibody (mAb) is a human IgG1 isotype produced in Chinese Hamster Ovary (CHO) cells. This antibody exhibits specific binding to the Spike (S1) protein of the SARS coronavirus, effectively blocking the virus's ability to infect susceptible cells. This mAb serves as a critical tool for research focused on the mechanisms of SARS virus entry and pathogenesis, and is suitable for use in virus neutralization studies and other virological applications.
Ebrasodebart is a human monoclonal antibody of the IgG4λ subtype that specifically targets TMEM219. For experimental rigor, the recommended isotype control is Human IgG4 (S228P) lambda1. This control is crucial for distinguishing specific from non-specific binding in assays involving Ebrasodebart.
Synonyms: RO5458640
RG-7212 (RO5458640) is a human-derived monoclonal antibody produced in Chinese Hamster Ovary (CHO) cells, specifically targeting TNFSF12/TWEAK. This antibody is comprised of a human IgG1 type heavy chain and a human kappa (huκ) type light chain. The predicted molecular weight of RG-7212 is approximately 146.02 kDa. For experimental control purposes, the appropriate isotype control is Human IgG1 kappa.
Synonyms: BAX69; Anti-Human MIF Recombinant Antibody
Imalumab (BAX69) is a recombinant human IgG1 monoclonal antibody specifically designed to target macrophage migration inhibitory factor (MIF). This antibody is utilized primarily in the study of ovarian carcinoma, recurrent malignant ascites, and various cancers, providing a critical tool for researchers investigating the role of MIF in tumor biology and immune response modulation.
The Anti-HGFA Antibody is a humanized monoclonal antibody specifically targeting hepatocyte growth factor activator (HGFA). Expressed in Chinese hamster ovary (CHO) cells, this antibody is composed of a human IgG1 heavy chain and a human kappa light chain, resulting in a predicted molecular weight of 150 kDa. For isotype control, researchers should use the Human IgG1 kappa, Isotype Control, ensuring accurate experimental comparisons. This antibody is essential for studies involving the regulation and modulation of HGFA, a key enzyme in tissue repair and regeneration processes.
Eclutatug is a humanized IgG1κ monoclonal antibody specifically targeting CLDN1. For experimental control purposes, it is recommended to use Human IgG1 kappa as an isotype control.
Synonyms: OMS 721; Anti-MASP2 Reference Antibody (narsoplimab
Narsoplimab (OMS 721) is a fully human monoclonal antibody of the immunoglobulin gamma 4 (IgG4) subclass, characterized by its high affinity for MASP-2, effectively inhibiting the activation of the lectin pathway. This antibody is pivotal in research focused on hematopoietic stem-cell transplantation and the study of SARS-CoV-2, offering significant insights into therapeutic interventions and immune response mechanisms.
The Anti-Complement Factor P/Properdin Antibody is a humanized monoclonal antibody produced in Chinese Hamster Ovary (CHO) cells. It specifically targets Complement Factor P, also known as Properdin, a critical component in the complement system that enhances the activation of the alternative pathway. This antibody is composed of a human IgG1 heavy chain and a human kappa light chain, and exhibits a molecular weight of approximately 150 kDa. For experimental control purposes, the recommended isotype control is Human IgG1 kappa, Isotype Control. This product is ideal for use in research applications focused on the study of immune response modulation and complement system mechanisms.
Rezorstobart is a human IgG1 κ monoclonal antibody targeting KLRB1. For optimal experimental control, it is recommended to use Human IgG1 kappa as an isotype control.
The Anti-Haptoglobin Antibody is a humanized monoclonal antibody produced in Chinese Hamster Ovary (CHO) cells. It specifically targets Haptoglobin, a key protein involved in hemoglobin binding and iron recovery. This antibody is constructed with a human IgG1 heavy chain and a human kappa light chain, and has a predicted molecular weight of 150 kDa. For isotype control purposes, Human IgG1 kappa, Isotype Control is recommended. This product is ideal for use in a variety of immunodetection methodologies to study or quantify Haptoglobin levels in biological samples.
The Anti-CD36 Antibody is a humanized monoclonal antibody produced in Chinese Hamster Ovary (CHO) cells, specifically designed to target CD36, a transmembrane glycoprotein involved in fatty acid metabolism, phagocytosis, and angiogenesis. This antibody consists of a human IgG1 heavy chain and a human kappa light chain, with an approximate molecular weight of 150 kDa. For isotype control purposes, Human IgG1 kappa, Isotype Control is recommended. This product is essential for research focusing on cardiovascular diseases, metabolic disorders, and immune response modulation.
The Anti-CD220/Insulin Receptor Antibody (IR 83-22) is a chimeric mouse monoclonal antibody of the IgG1 subclass, specifically designed to target the human CD220, also known as the Insulin Receptor. This antibody recognizes and binds to the insulin receptor, facilitating studies on receptor expression and function in various biological contexts. For accurate isotype control in experimental setups, it is recommended to use Mouse IgG1 kappa Isotype Control to ensure specificity and consistency in results.
Synonyms: SC-005 antibody
The Anti-Melanotransferrin/CD228 Antibody (SC-005 antibody) is a humanized monoclonal antibody produced in Chinese Hamster Ovary (CHO) cells. It specifically targets Melanotransferrin, also known as CD228. This antibody is comprised of a human IgG1 heavy chain and a human kappa light chain, and exhibits a predicted molecular weight of 145.16 kDa. For isotype control experiments, the Human IgG1 kappa, Isotype Control is recommended. This antibody is suitable for a variety of research applications focusing on the biological functions and pathological roles of Melanotransferrin/CD228.
Pritumumab is a naturally derived human monoclonal antibody of the IgG1 kappa subclass, initially isolated from a regional draining lymph node in a patient diagnosed with cervical carcinoma. This antibody specifically targets vimentin displayed on the surface of malignant tumor cells. It is particularly useful in the study of glioblastoma, offering potential insights into the pathology and therapeutic targeting of this aggressive cancer type.
Synonyms: Gomiliximab; IDEC-152; ST-152
Lumiliximab, a recombinant anti-CD23 monoclonal antibody, effectively inhibits allergen-induced responses by targeting the CD23 receptor. This antibody serves as a crucial tool in immunological research, particularly in studies related to allergic reactions and immune regulation. Lumiliximab's specificity for CD23 makes it ideal for investigating the role of this receptor in various immunological processes and potential therapeutic applications.
The Anti-GPC-2 Antibody (CT3) is a chimeric mouse monoclonal antibody of the IgG1 kappa subtype, specifically designed to target human Glypican-2 (GPC-2). For accurate experimental control, it is recommended to use Mouse IgG1 kappa Isotype Control. This antibody serves as a vital tool for the detection and study of GPC-2 expression in various research applications.
The Anti-CLEC14A Antibody is a humanized monoclonal antibody produced in Chinese Hamster Ovary (CHO) cells, specifically designed to target CLEC14A, a marker implicated in angiogenesis and tumor biology. This antibody comprises an IgG1 heavy chain and a human kappa (huκ) light chain, exhibiting a predicted molecular weight of approximately 150 kDa. For isotype control in experimental procedures, the Human IgG1 kappa, Isotype Control is recommended. This product is essential for research focused on cancer, vascular biology, and related therapeutic development.
Synonyms: PB 2452; MEDI 2452
Bentracimab (PB 2452) is a high-affinity neutralizing monoclonal antibody designed to specifically bind to Ticagrelor and its major active circulating metabolite. This antibody is capable of rapidly reversing the antiplatelet effects of Ticagrelor, making it an essential tool for research into the pharmacodynamics and therapeutic management of Ticagrelor-induced platelet inhibition. Bentracimab offers significant potential for studies focused on cardiovascular therapeutics and anticoagulant reversal strategies.
The Anti-CD32/FcγRIIA Antibody (IV.3) is a chimeric monoclonal antibody of the mouse IgG2b class, specifically designed to target human CD32/FcγRIIA. This antibody serves as a critical tool for the study of immune response modulation via Fc receptors. For accurate experimental control, it is recommended to use Mouse IgG2b kappa as the isotype control. This antibody is ideal for applications in immunology research, particularly in the investigation of Fc receptor function and its role in disease pathogenesis.
Synonyms: LT 1009; Anti-Human S1P Recombinant Antibody
Sonepcizumab (LT 1009) is a fully human monoclonal antibody targeting sphingosine-1-phosphate (S1P). This antibody is designed for investigational use in studies focusing on metastatic renal cell carcinoma (mRCC), offering a potential tool for understanding the role of S1P in tumor progression and metastasis.
Synonyms: Olizumab; rhuMab-E25
Omalizumab is a recombinant, humanized monoclonal antibody that selectively targets human immunoglobulin E (IgE), exhibiting a dissociation constant (K_D) of 0.393 nM. This antibody also interacts with human FcγRIIb receptors, with a K_D of 6.37 µM. Due to its specific mechanism of action, Omalizumab is extensively used in research focusing on persistent allergic asthma, providing a valuable tool for investigations into the pathophysiology and potential therapeutic interventions for this condition.
