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Aldehyde Dehydrogenase (ALDH)

Aldehyde dehydrogenase (ALDH) inhibitors and activators target enzymes that oxidize aldehydes to carboxylic acids. The human ALDH superfamily uses NAD+ as cofactor and includes cytosolic ALDH1A1 and mitochondrial ALDH2. ALDH2 removes acetaldehyde and lipid peroxidation products such as 4-hydroxynonenal. In 2008 the small-molecule activator Alda-1 increased ALDH2 activity and reduced ischemic damage in rat hearts. High ALDH1 activity was reported in 2007 as a marker of normal and malignant human mammary stem cells. NCT-501, NCT-505 and NCT-506 inhibit ALDH1A1 and are used in cancer stem cell studies. RV01 targets ALDH2, while dyclonine hydrochloride and the herbicide propachlor also inhibit ALDH isoforms.

2 Items

  • 3-Hydroxybenzaldehyde
    Cat. No.
    A40755
    CAS No.
    100-83-4

    3-Hydroxybenzaldehyde

    Synonyms: M-Hydroxybenzaldehyde

    3-Hydroxybenzaldehyde serves as a substrate for aldehyde dehydrogenase (ALDH) and acts as a precursor for diverse phenolic compounds, including Protocatechuic aldehyde. This compound exhibits vasculoprotective properties, demonstrating potential in both in vitro and in vivo studies. Research applications primarily focus on its role in atherosclerosis, making it a valuable reagent for biochemical investigations related to cardiovascular health.

    In stock View Details
    5 g
    $20.00
    25 g
    $25.00
    All 5 sizes
  • BODIPY aminoacetaldehyde diethyl acetal
    Cat. No.
    B11063
    CAS No.
    247069-93-8

    BODIPY aminoacetaldehyde diethyl acetal

    Synonyms: BAAA-DA

    BODIPY aminoacetaldehyde diethyl acetal is a stable precursor to BODIPY-aminoacetaldehyde, which serves as a fluorescent substrate for aldehyde dehydrogenase (ALDH). Under acidic conditions, it can be efficiently converted into BODIPY-aminoacetaldehyde, facilitating studies of ALDH activity and function. This reagent is valuable for applications in fluorescence microscopy, biochemical assays, and other research areas focused on enzymatic activity and metabolic pathways.

    In stock View Details
    1 mg
    $155.00
    5 mg
    $245.00
    All 6 sizes

2 Items

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