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Stearoyl-CoA Desaturase (SCD)

SCD inhibitors block stearoyl-CoA desaturase, the enzyme that makes monounsaturated fatty acids. Stearoyl-coenzyme A desaturase (SCD) inserts a cis double bond at the delta-9 position of palmitoyl-CoA and stearoyl-CoA. Its products, palmitoleate and oleate, are built into triglycerides, phospholipids and cholesteryl esters. In 2002, mice lacking SCD1 were shown to be protected against adiposity, which drew interest to the enzyme in metabolic research. A 2015 X-ray structure of mouse SCD1 showed how this membrane enzyme holds its acyl-CoA substrate. A939572, CAY10566 and XEN723 are SCD1 inhibitors, and MK-8245 was designed to act mainly in the liver. SC-26196 inhibits delta-6 desaturase instead, a related fatty acid desaturase.

2 Items

  • 18:0 Coenzyme A triammonium
    Cat. No.
    A72247
    CAS No.
    799812-87-6

    18:0 Coenzyme A triammonium

    18:0 Coenzyme A (triammonium) is a substrate for stearoyl-CoA desaturases (SCDs), enzymes that catalyze the desaturation of saturated fatty acids. This compound plays a crucial role in lipid metabolism and is significant in studies focused on fatty acid synthesis and oxidation. It is widely used in research applications investigating metabolic disorders and adipocyte differentiation.

    In stock View Details
    1 mg
    $310.00
    5 mg
    $945.00
    All 2 sizes
  • Stearoyl coenzyme A lithium
    Cat. No.
    A88493
    CAS No.
    193402-48-1

    Stearoyl coenzyme A lithium

    Synonyms: Stearoyl-CoA lithium

    Stearoyl coenzyme A lithium is an active compound utilized as a substrate for the enzymatic activity of stearoyl-CoA desaturase in microsomal preparations. This reagent is important for studying lipid metabolism, particularly in the context of fatty acid desaturation processes. Applications include exploring the role of stearoyl-CoA desaturase in cellular function and investigating related metabolic pathways in biochemical research.

    In stock View Details
    1 mg
    $200.00
    5 mg
    $445.00
    All 2 sizes

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