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N-myristoyltransferase (NMT)

N-myristoyltransferase (NMT) inhibitors block myristic acid attachment to protein N-terminal glycines. NMT transfers the 14-carbon myristoyl group from myristoyl coenzyme A, usually during translation after the initiator methionine is removed. The modification helps proteins such as Src family kinases bind membranes. Humans have two isozymes, NMT1 and NMT2, and a 2014 proteomic study mapped myristoylated proteins in human cells. DDD85646 was described in 2010 as an inhibitor of Trypanosoma brucei NMT that is lethal to the sleeping sickness parasite. IMP-1088 inhibits human NMT1 and NMT2 and was shown in 2018 to block rhinovirus capsid assembly. SC-58272 targets the Candida albicans enzyme, and myristoyl coenzyme A lithium is also listed.

1 Item

  • 3-Thiatetradecanoic acid
    Cat. No.
    A40078
    CAS No.
    116296-31-2

    3-Thiatetradecanoic acid

    3-Thiatetradecanoic acid is a fatty acid substrate for N-myristoyltransferase (NMT), playing a pivotal role in the metabolism of thiofatty acids. This compound is utilized in research studying lipid metabolism and protein modification processes, particularly in the context of membrane protein dynamics. Its unique properties enable investigations into the biological implications of thiofatty acids in various cellular environments.

    In stock View Details
    5 mg
    $420.00
    10 mg
    $685.00
    All 2 sizes

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