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DHFR

Dihydrofolate reductase (DHFR) inhibitors block the enzyme that reduces dihydrofolate to tetrahydrofolate. Tetrahydrofolate carries one-carbon units for the synthesis of thymidylate, purines and several amino acids, so DHFR inhibition starves dividing cells of DNA precursors. In 1958 aminopterin and amethopterin, the compound now called methotrexate, were shown to inhibit the enzyme. Methotrexate, aminopterin and pralatrexate are classical antifolates, whereas the lipophilic trimetrexate enters cells without the folate carrier. Pemetrexed, described in 1997 as LY231514, also inhibits thymidylate synthase and glycinamide ribonucleotide formyltransferase. Proguanil, whose metabolite cycloguanil acts on the parasite enzyme, and the diaminopyrimidine diaveridine represent inhibitors of microbial DHFR.

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  • 10-Formyl-7,8-dihydrofolic acid
    Cat. No.
    A43975
    CAS No.
    28459-40-7

    10-Formyl-7,8-dihydrofolic acid

    10-Formyl-7,8-dihydrofolic acid is a potent substrate for dihydrofolate reductase (DHFR) and aminoimidazolecarboxamide ribonucleotide transformylase. It plays a significant role in promoting the growth of leukemia cells and can effectively reverse growth inhibition caused by antifolate medications in folate-deficient environments. This compound is valuable for research applications focused on leukemia and related therapeutic strategies.

    In stock View Details
    1 mg
    $155.00
    All 1 sizes

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