PPAR

Cat. No.

A15454

CAS No.

923978-27-2

Elafibranor

Synonyms: GFT505

Elafibranor is an agonist of the peroxisome proliferator-activated Receptor-α and -δ, induces resolution of nonalcoholic steatohepatitis without fibrosis worsening.

Cat. No.

A11981

CAS No.

97322-87-7

Troglitazone

Synonyms: Rezulin

Troglitazone is a selective PPARγ receptor agonist (EC50 values are 780 and 555 nM at murine and human PPARγ receptors respectively).

Cat. No.

A10807

CAS No.

122320-73-4

Rosiglitazone (BRL-49653)

Synonyms: Avandia; BRL-49653

Rosiglitazone works as an insulin sensitizer, by binding to the PPAR receptors in fat cells and making the cells more responsive to insulin.

Cat. No.

A10809

CAS No.

155141-29-0

Rosiglitazone maleate

Synonyms: Avandia; Avandamet; Avandaryl

Rosiglitazone maleate, an antidiabetic drug, works as an insulin sensitizer, by binding to the PPAR receptors in fat cells and making the cells more responsive to insulin.

Cat. No.

A10570

CAS No.

89-57-6

5-Aminosalicylic Acid

Synonyms: Mesalamine; 5-ASA; Mesalazine

5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.

Cat. No.

A11636

CAS No.

302543-62-0

Rosiglitazone hydrochloride

Synonyms: BRL 49653 hydrochloride

Rosiglitazone hydrochloride is a selective agonist of the peroxisome proliferator-activated receptor gamma (PPARγ), demonstrating an EC50 of 60 nM and a Kd of 40 nM. In addition to its primary action, it acts as a TRPC5 activator with an EC50 of 30 μM and a TRPM3 inhibitor. This compound is extensively utilized in research related to obesity, diabetes, cellular senescence, and ovarian cancer.

Cat. No.

A11680

CAS No.

111025-46-8

Pioglitazone (Actos)

Synonyms: Actos

Pioglitazone selectively stimulates the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-γ) and to a lesser extent PPAR-α.

Cat. No.

A11727

CAS No.

52214-84-3

Ciprofibrate

Ciprofibrate is a peroxisome proliferator-activated receptor agonist.

Cat. No.

A11900

CAS No.

6197-30-4

Octocrylene

Octocrylene is an organic ultraviolet (UV) filter primarily known for absorbing UVB radiation and shorter UVA wavelengths. This compound acts as a partial agonist of PPARγ, influencing the transcription profiles of lipid metabolism enzymes. Additionally, Octocrylene exhibits cytotoxic and genotoxic effects on human skin fibroblasts and has been shown to mediate the biosynthesis of estrogens, such as estriol, in zebrafish larvae while impacting antioxidant pathways, including glutathione transferase and peroxisomes. Its applications include studies in photoprotection, environmental toxicology, and endocrine disruption research.

Cat. No.

A11982

CAS No.

265129-71-3

GW 7647

GW 7647 is a potent and highly selective PPARα agonist (EC50 values are 6, 1100 and 6200 nM for human PPARα, PPARγ and PPARδ receptors respectively).

Cat. No.

A11983

CAS No.

79558-09-1

L-165,041

Synonyms: L-165041

L-165,041 is a potent PPARδ agonist (Ki = 6 nM); displays > 100-fold selectivity for both mouse and human PPARδ receptors over other subtypes.

Cat. No.

A12360

CAS No.

50892-23-4

pirinixic acid (WY 14643)

Synonyms: WY 14643

WY 14643 is a highly potent PPARα agonist.

Cat. No.

A12492

CAS No.

475479-34-6

Aleglitazar

Synonyms: R1439; RO0728804

Aleglitazar is a new dual PPAR-α/γ agonist with IC50 of 2.8 nM/4.6 nM.

Cat. No.

A12701

CAS No.

743438-45-1

Chiglitazar

Chiglitazar is a PPARα/γ dual agonist, with EC50s of 1.2, 0.08, 1.7 μM for PPARα, PPARγ and PPARδ, respectively.

Cat. No.

A13262

CAS No.

870884-12-1

Pparδ agonist 2

Pparδ agonist 2 is a PPARδ agonist extracted from patent WO 2016057656 A1.

Cat. No.

A14958

CAS No.

317318-84-6

GW0742

GW0742 is a selective agonist of PPARδ with EC50 value of 1.1 nM.

Cat. No.

A15013

CAS No.

199113-98-9

Balaglitazone

Synonyms: DRF-2593; NN-2344

Balaglitazone is a novel partial agonist of PPAR-gamma (γ).

Cat. No.

A15099

CAS No.

196808-24-9

GW1929

GW1929 is a synthetic peroxisome proliferator-activated receptor-γ (PPARγ) agonist with IC50 of 6.2 nM and 13 nM for human and mouse, respectively.

Cat. No.

A15129

CAS No.

223132-38-5

Inolitazone dihydrochloride

Synonyms: Efatutazone; CS-7017; RS5444

Inolitazone dihydrochloride is a novel high-affinity PPARγ agonist, which activates PPARγ with an EC50 about 1/50 that of rosiglitazone and has no effect on RIE cells.

Cat. No.

A15604

CAS No.

1740-19-8

Dehydroabietic acid

Dehydroabietic acid is a diterpene resin acid that serves as a dual agonist for PPAR-α and PPAR-γ, with partial agonist activity at PPAR-γ. This compound exhibits significant biological activities, including anti-bacterial, anti-fungal, anti-inflammatory, and anti-cancer effects. It has been shown to mitigate insulin resistance and hepatic steatosis induced by high-fat diet consumption in animal models, making it a valuable reagent for research in metabolic disorders and inflammatory diseases.

Cat. No.

A15651

CAS No.

36052-37-6

Alpinetin

Alpinetin is a flavonoid that acts as a PPAR-γ activator, demonstrating significant anti-inflammatory and hepatoprotective properties. It effectively inhibits lipopolysaccharide (LPS)-induced inflammation and protects against LPS-induced renal injury by modulating TLR4 expression and activating the Nrf2 pathway. Its diverse biological activities make Alpinetin a valuable reagent for research into tumor biology, cardiovascular health, and neuroprotection.

Cat. No.

A15680

CAS No.

521-32-4

Bilobetin

Bilobetin acts as a PPARα activator, enhancing lipid metabolism and insulin sensitivity. It effectively reduces blood lipid levels by promoting hepatic lipid uptake and oxidation, while decreasing triglyceride secretion and accumulation in tissues. Additionally, Bilobetin stimulates the phosphorylation and nuclear translocation of PPARα, resulting in increased cAMP levels and PKA activity. This compound is significant for research in metabolic disorders, particularly those related to insulin resistance and lipid regulation.

Cat. No.

A15695

CAS No.

57396-78-8

Oroxin A

Oroxin A is a partial agonist of the peroxisome proliferator-activated receptor gamma (PPARγ). It enhances PPARγ transcriptional activity through binding to the PPARγ ligand-binding domain. Additionally, Oroxin A demonstrates inhibitory effects on α-glucosidase and possesses antioxidant properties. Its anti-breast cancer potential is attributed to the induction of endoplasmic reticulum stress-mediated cellular senescence, making it a valuable tool for research in metabolic and cancer biology.

Cat. No.

A15707

CAS No.

66056-22-2

Angeloylgomisin H

Angeloylgomisin H is a PPAR-γ activator derived from the lignin extract of Schisandra rubriflora. This compound has demonstrated the ability to enhance insulin-stimulated glucose uptake, making it a valuable candidate for research in metabolic disorders and diabetes. Its mechanism of action may provide insights into therapeutic strategies aimed at improving insulin sensitivity and glucose metabolism.

Cat. No.

A15836

CAS No.

1000998-59-3

BMS-687453

BMS-687453 is a potent and selective peroxisome proliferator activated receptor (PPAR) alpha agonist, with an EC(50) of 10 nM for human PPARalpha and approximately 410-fold selectivity vs human PPARgamma in PPAR-GAL4 transactivation assays.