Myosin

Cat. No.

A11206

CAS No.

873697-71-3

Omecamtiv mecarbil (CK-1827452)

Synonyms: CK1827452

CK-1827452 is a selective cardiac specific myosin activator.

Cat. No.

A10495

CAS No.

520-18-3

Kaempferol

Kaempferol is found to inhibit bovine aorta myosin light chain kinase with a Ki of 0.3-0.5 microM and also is found to inhibit VEGF expression and in vitro angiogenesis through a novel ERK-NFκB-cMyc-p21 pathway.

Cat. No.

A15757

CAS No.

99-93-4

4-Hydroxyacetophenone

Synonyms: P-hydroxyacetophenone

4-Hydroxyacetophenone is a potent myosin activator that has demonstrated hepatoprotective and choleretic properties. This compound exhibits antiviral and anti-inflammatory activities, particularly against hepatitis B virus, and is known to inhibit cancer cell adhesion, invasion, and migration through actin remodeling. Its diverse biological activities make 4-Hydroxyacetophenone a valuable reagent for research in inflammatory diseases and cancer studies.

Cat. No.

A19326

CAS No.

1642288-47-8

Mavacamten

Synonyms: MYK461; SAR439152

Mavacamten is a modulator of cardiac myosin, with IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively.

Cat. No.

A57583

CAS No.

1970972-74-7

Danicamtiv

Synonyms: MYK-491

Danicamtiv is a selective allosteric activator of cardiac myosin, serving as a cardiac inotropic agent. It enhances cardiac systolic function while maintaining mechanical efficiency, making it a valuable tool for research on heart failure and myocardial contractility. This compound is instrumental in studying the modulation of cardiac contractile function and understanding its implications in cardiovascular diseases.

Cat. No.

A57613

CAS No.

3034189-56-2

Myosin modulator 1

Myosin Modulator 1 is a selective modulator of myosin that inhibits ATPase activity in rabbit psoas, porcine atrial, and porcine ventricular tissues, exhibiting IC25 values of 0.42, 0.13, and 3.09 μM, respectively. This compound plays a significant role in regulating systolic cardiac performance, making it a valuable tool for research in cardiac physiology and myosin-related studies.

Cat. No.

A57614

CAS No.

3034189-87-9

Myosin modulator 2

Myosin Modulator 2 (Compound B172) is a modulator of myosin that selectively inhibits ATPase activity in rabbit psoas muscle, porcine atria, and porcine ventricles, with IC25 values of 2.013 μM, 2.94 μM, and 20.93 μM, respectively. This compound demonstrates significant regulation of systolic cardiac performance in Sprague Dawley rats, making it a valuable tool in cardiac physiology research and drug development studies focusing on muscle contractility and cardiovascular function.