Protein Disulfide Isomerase (PDI)

Cat. No.

A19466

CAS No.

32502-62-8

3-Methyltoxoflavin

Synonyms: GNF-Pf-2272

3-Methyltoxoflavin is a potent Protein disulfide isomerase (PDI) inhibitor, with an IC50 of 170 nM.

Cat. No.

A20491

CAS No.

877963-94-5

LOC14

LOC14 is a potent Protein disulfide isomerase (PDI) inhibitor with EC50 and Kd values of 500 nM and 62 nM, respectively.

Cat. No.

A30244

CAS No.

2285446-62-8

E64FC26

E64FC26 is a potent inhibitor of the protein disulfide isomerase (PDI) family, demonstrating IC50 values of 1.9 μM for PDIA1, 20.9 μM for PDIA3, 25.9 μM for PDIA4, 16.3 μM for TXNDC5, and 25.4 μM for PDIA6. This compound exhibits significant anti-myeloma activity, making it a valuable tool for cancer research focused on targeting PDI-related pathways. Its ability to modulate protein folding processes positions E64FC26 as a promising candidate in studies aimed at understanding the role of PDIs in various diseases.

Cat. No.

A53751

CAS No.

3097563-91-9

PDI-IN-5

PDI-IN-5 is an allosteric-covalent inhibitor targeting protein disulfide isomerase (PDI), featuring a 2-chloro-pyrrolopyrimidin-4-one scaffold with an IC50 of 0.4 μM. This compound demonstrates selectivity for ERp57 and GPX4, and has been shown to inhibit glioblastoma cell proliferation. PDI-IN-5 is valuable for research focused on glioblastoma and studies involving protein folding and oxidative stress responses.

Cat. No.

A56846

CAS No.

1401089-31-3

PACMA 31

PACMA 31 is an irreversible inhibitor of protein disulfide isomerase (PDI) that demonstrates an IC50 of 10 μM. By forming covalent bonds with the active site cysteines of PDI, PACMA 31 effectively suppresses ovarian tumor growth while preserving the integrity of normal tissues. Additionally, PACMA 31 serves as a versatile click chemistry reagent, featuring an alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, making it suitable for various biochemical applications.

Cat. No.

A56849

CAS No.

1069858-99-6

ML359

ML359 is a selective and reversible inhibitor of protein disulfide isomerase (PDI), with an IC50 of 250 nM. This compound effectively disrupts PDI activity, leading to an inhibition of thrombus formation in vivo. ML359 is valuable in research related to cardiovascular diseases and the modulation of protein folding processes.

Cat. No.

A56850

CAS No.

922507-80-0

PDI-IN-3

PDI-IN-3 is a potent inhibitor of protein disulfide isomerase (PDI), a key enzyme involved in protein folding and redox regulation. This compound has been shown to disrupt cellular viability, making it a valuable tool for studying PDI's role in cancer biology and cellular stress responses. Its application in research can help elucidate the mechanisms underlying PDI-related pathways and potential therapeutic interventions.

Cat. No.

A56853

CAS No.

1461648-55-4

PDI-IN-1

PDI-IN-1 is a cell-permeable inhibitor of human protein disulfide isomerase (PDI), exhibiting an IC50 of 1.7 μM. With demonstrated anti-cancer activity, PDI-IN-1 serves as a valuable tool for research applications targeting cancer biology and the role of protein misfolding in tumor development. It is suitable for in vitro studies aimed at elucidating the therapeutic potential of PDI inhibition in cancer treatment.

Cat. No.

B21847

CAS No.

16408-78-9

Dicentrinone

Dicentrinone is an orally active inhibitor of Protein Disulfide Isomerase (PDI), with an IC50 value of 43.95 μM. By directly binding to PDI, Dicentrinone effectively suppresses cell proliferation and reduces the viability of cancer cells. Additionally, it exhibits anti-inflammatory and antioxidant properties through the inhibition of leukocyte migration, reduction of plasma leakage and paw edema, and scavenging of free radicals. Dicentrinone is a valuable tool in the study of hepatoma, rheumatism, and arthritis.