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Pregnane X Receptors

Pregnane X receptor (PXR) agonists activate a nuclear receptor that senses foreign compounds. PXR was reported in 1998 as an orphan nuclear receptor activated by pregnane steroids. In the same year, human PXR was shown to respond to compounds that induce cytochrome P450 3A4 (CYP3A4) and cause drug interactions. Ligand-bound PXR pairs with retinoid X receptor (RXR) and raises the expression of drug-metabolizing enzymes and transporters in liver and intestine. Rifampin and SR-12813 activate human PXR, while pregnenolone 16α-carbonitrile is the classic rodent agonist. Other listed activators include (3S,5S)-Atorvastatin, SJPYT-328, isobutylparaben and the bile acid precursor 7α-Hydroxy-4-cholesten-3-one.

1 Item

  • SJPYT-310
    Cat. No.
    A85379
    CAS No.
    2883814-84-2

    SJPYT-310

    SJPYT-310 is a selective ligand for the Pregnane X Receptor (PXR), functioning as an antagonist. This compound effectively inhibits PXR-mediated transcriptional activity, providing insights into drug metabolism and cellular responses to xenobiotics. SJPYT-310 is suitable for research applications exploring the role of PXR in pharmacology and toxicology, while demonstrating a favorable safety profile with no significant cytotoxicity observed.

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    5 mg
    $120.00
    10 mg
    $245.00
    All 4 sizes

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