Orphan Nuclear Receptor | Adooq Bioscience

Cat. No.: A59497

CAS No.: 351490-72-7

SB-423562 hydrochloride

SB-423562 hydrochloride is a potent calcium-sensing receptor (CaR) antagonist. It exhibits strong inhibitory effects on CaR signaling, making it a valuable tool for investigating calcium homeostasis and related metabolic disorders. This compound is particularly applicable in osteoporosis research, providing insights into bone density regulation and potential therapeutic interventions.

In stock View Details

All 3 sizes

Cat. No.: A85353

CAS No.: 337506-43-1

BIM5078

BIM5078 is an antagonist of hepatocyte nuclear factor 4α (HNF4α), which effectively inhibits the expression of target genes regulated by HNF4α. This compound has been shown to repress insulin promoter activity, making it a valuable tool for studying the roles of HNF4α in metabolic disorders. BIM5078 is utilized in research focusing on cancer and diabetes, contributing to the understanding of these diseases at a molecular level.

In stock View Details

All 4 sizes

Cat. No.: A85357

CAS No.: 93987-29-2

BI-6015

BI-6015 is an antagonist of hepatocyte nuclear factor 4α (HNF4α), effectively inhibiting the expression of HNF4α target genes. By repressing insulin promoter activity, it serves as a valuable tool for studying the regulatory mechanisms governed by HNF4α. BI-6015 is applicable in research focused on cancer and diabetes, providing insights into metabolic and oncogenic pathways.

In stock View Details

2 mg

$30.00

5 mg

$45.00

All 7 sizes

7-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene

Cat. No.: A85363

CAS No.: 1159977-58-8

7-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene

7-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene is an LRH-1 antagonist, exhibiting an IC50 of 3.1 μM. This compound is valuable for studying the role of LRH-1 in various biological processes, including lipid metabolism and endocrine signaling. Its pharmacological properties make it a suitable tool for investigating potential therapeutic targets in metabolic diseases and hormone-related conditions.

In stock View Details

5 mg

$230.00

10 mg

$380.00

All 5 sizes

Cat. No.: A85373

CAS No.: 1185486-16-1

LRH-1 antagonist-1

LRH-1 antagonist-1 is a selective antagonist of Liver Receptor Homolog-1 (LRH-1) with a Kd of 1.8 μM. This compound effectively inhibits the transcriptional activity of LRH-1, leading to reduced expression of G0S2 and subsequent inhibition of proliferation in LRH-1-positive cancer cells. It is suitable for research applications in pancreatic, colon, and breast cancer studies, where targeting LRH-1 may provide valuable insights into tumor growth and progression.

View Details

Out of stock

All 3 sizes

Cat. No.: A85376

CAS No.: 2932459-63-5

LRH-1 antagonist-1 dihydrochloride

LRH-1 antagonist-1 dihydrochloride is a selective antagonist of Liver Receptor Homolog-1 (LRH-1), exhibiting a Kd of 1.8 μM. This compound effectively inhibits the transcriptional activity of LRH-1, leading to a decrease in the expression of G0S2. Furthermore, it demonstrates the ability to suppress the proliferation of LRH-1-positive cancer cells, making it a valuable tool for research in pancreatic, colon, and breast cancer.

View Details

Out of stock

All 3 sizes