- Cat. No.
- A22100
SR8278
SR8278 is a competitive nuclear heme receptor REV-ERB synthetic antagonist.
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Reverse erythroblastosis virus (REV-ERB) nuclear receptors regulate circadian gene expression. The alpha and beta receptors act as transcriptional repressors within networks connecting daily rhythms and metabolism. This category includes SR9009, SR9011 and GSK4112, catalogued as agonists, together with the antagonist SR8278. These annotations distinguish different approaches to receptor-related research without implying identical target profiles. The selection is relevant to studies of clock-associated transcription and metabolic regulation, with compound-specific properties described in the individual entries.
SR8278 is a competitive nuclear heme receptor REV-ERB synthetic antagonist.