PARP

Cat. No.

A22090

CAS No.

1563007-08-8

G244-LM

G244-LM is a potent and specific tankyrase 1/2 inhibitor that inhibits Wnt signaling.

Cat. No.

A22220

CAS No.

2381037-82-5

Atamparib (RBN-2397)

Synonyms: RBN-2397

RBN-2397 is a potent, accross species and orally active NAD+ competitive inhibitor of PARP7 (IC50

Cat. No.

A22505

CAS No.

6336-34-1

OUL35

Synonyms: NSC39047

OUL35, also known as NSC39047, is a selective PARP-10 inhibitor, and small-molecule ARTD10 inhibitor.

Cat. No.

A25172

CAS No.

684234-55-7

PARP-1-IN-2

PARP-1-IN-2 is a potent inhibitor of PARP1, exhibiting an IC50 value of 149 nM. This compound demonstrates significant anti-proliferative effects on the A549 human lung adenocarcinoma epithelial cell line and induces apoptosis in these cells. Its favorable ADME profile suggests high permeability across the blood-brain barrier, making it a valuable tool for research in cancer biology and therapeutic applications targeting PARP1-related pathways.

Cat. No.

A25360

CAS No.

2265910-52-7

4,4′-Secalonic acid D

4,4′-Secalonic acid D is a potent inhibitor of PARP1, a key enzyme in the DNA repair pathway. This compound promotes the accumulation of reactive oxygen species (ROS) and DNA damage, leading to the activation of the caspase-3/GSDME pathway, which triggers apoptosis and pyroptosis in tumor cells. 4,4′-Secalonic acid D exhibits significant anti-tumor activity, making it a valuable tool for cancer research and therapeutic investigations.

Cat. No.

A25447

CAS No.

2976342-33-1

PARP-1-IN-3

PARP-1-IN-3 is a potent inhibitor of PARP-1, with IC50 values of 0.25 nM for PARP-1 and 2.34 nM for PARP-2. This benzamide derivative effectively induces apoptosis and leads to G2/M phase cell cycle arrest. PARP-1-IN-3 is valuable for research applications focused on cancer mechanisms and therapeutic strategies.

Cat. No.

A26436

CAS No.

3032621-10-3

PARP-1/HDAC-IN-1

PARP-1/HDAC-IN-1 is a dual inhibitor targeting PARP-1 and HDAC6, exhibiting IC50 values of 68.90 nM and 510 nM, respectively. This compound demonstrates significant anticancer properties, as well as anti-migration and anti-angiogenesis activities. Its applications are relevant in cancer research, particularly in studies exploring the modulation of DNA repair mechanisms and cellular signaling pathways.

Cat. No.

A26658

CAS No.

2687273-52-3

PARP/EZH2-IN-1

PARP/EZH2-IN-1 is a potent dual inhibitor targeting PARP and EZH2, with respective IC50 values of 6.87 nM and 36.51 nM. This reagent demonstrates significant biological activity in the treatment of triple-negative breast cancer, particularly in cells with wild-type BRCA. Its unique mechanism of action makes it a valuable tool for research into cancer biology and therapeutic development.

Cat. No.

A28950

CAS No.

609848-02-4

CEP-6800

CEP-6800 is a potent inhibitor of PARP-1, known for its ability to enhance the efficacy of chemotherapeutic agents. It effectively reduces poly(ADP-ribose) accumulation induced by irinotecan and temozolomide in LoVo and HT29 xenograft models. Additionally, CEP-6800 demonstrates potential in suppressing tumor growth in Calu-6. This compound is valuable for research in cancer biology and therapy development.

Cat. No.

A28952

CAS No.

1903744-45-5

PARP-1/2-IN-1

PARP-1/2-IN-1 is a highly effective inhibitor of the poly(ADP-ribose) polymerases PARP-1 and PARP-2, exhibiting IC50 values of 0.51 nM and 23.11 nM, respectively. This compound plays a critical role in cancer research by targeting DNA repair mechanisms, enhancing the efficacy of chemotherapeutic agents, and potentially improving cancer treatment outcomes. It is a valuable tool for studying PARP-related cellular processes and investigating therapeutic strategies in oncology.

Cat. No.

A28953

CAS No.

916574-83-9

CEP-9722

CEP-9722 is a selective, orally active inhibitor of PARP-1 and PARP-2, exhibiting IC50 values of 20 nM and 6 nM, respectively. This compound demonstrates significant anticancer activity, making it a valuable tool for research in cancer therapy and DNA repair mechanisms. Its ability to inhibit these critical enzymes positions CEP-9722 as an important reagent for studying cellular responses to DNA damage and tumor susceptibility to therapeutic agents.

Cat. No.

A28954

CAS No.

3034666-02-6

PARP7-IN-21

PARP7-IN-21 is a potent inhibitor of PARP7, demonstrating an IC50 of less than 10 nM. This compound effectively interferes with the activity of PARP7, which is involved in the regulation of cellular processes such as DNA repair and signaling pathways related to stress response. PARP7-IN-21 is valuable for research applications focused on cancer biology, neurodegenerative diseases, and other conditions associated with PARP7 dysregulation.

Cat. No.

A28955

CAS No.

3032818-67-7

CDK9/PARP-IN-1

CDK9/PARP-IN-1 is a potent inhibitor of CDK9 and PARP1, demonstrating IC50 values of 118 nM and 107 nM, respectively. This dual inhibition results in significant antiproliferative effects across various cancer cell lines, making it a valuable tool for cancer research. CDK9/PARP-IN-1 is particularly relevant for studies investigating the therapeutic potential of targeting these pathways in oncology.

Cat. No.

A28956

CAS No.

2245272-16-4

Antitumor agent-104

Antitumor agent-104 is a potent inhibitor of PARP1 and CDK12, targeting critical pathways in DNA damage repair in tumors. By inhibiting PARP1 enzymatic activity, it effectively reduces PAR protein levels, thus impairing the cellular mechanisms that protect tumor cells. This compound serves as a valuable tool in cancer research, especially in studies focused on understanding tumor biology and exploring novel therapeutic strategies.

Cat. No.

A28957

CAS No.

3087853-45-7

PARP1-IN-53

PARP1-IN-53 is a potent PARP1 inhibitor with an IC50 of 0.1 nM, demonstrating high selectivity over PARP2, which has an IC50 of 23 nM. This quinazolinone derivative effectively interferes with the poly(ADP-ribose) polymerase 1 enzyme, making it a valuable compound for cancer research. Its specific action on PARP1 enables detailed studies into the mechanisms of DNA repair and cell survival in oncology.

Cat. No.

A28958

CAS No.

2580941-64-4

TNKS-2-IN-3

TNKS-2-IN-3 is a selective competitive inhibitor of tankyrase 2 (TNKS2), demonstrating an IC50 value of 0.3 nM and exhibiting over 20-fold selectivity against TNKS1, along with more than 100-fold selectivity over PARP1/2. By inhibiting TNKS2-mediated ADP-ribosylation, TNKS-2-IN-3 stabilizes axin and effectively suppresses the Wnt/β-catenin signaling pathway. This compound shows promising antiproliferative activity in colorectal cancer cells and is relevant for research focused on solid tumors characterized by dysregulated Wnt pathway activation, particularly in colorectal cancer.

Cat. No.

A28960

CAS No.

501364-91-6

INO-1001 mesylate

INO-1001 mesylate is a selective inhibitor of poly (ADP-ribose) polymerase (PARP), a critical enzyme involved in DNA repair processes. It enhances the sensitivity of cancer cells to radiation therapy by disrupting DNA repair mechanisms, leading to increased necrotic cell death. This compound is of interest in cancer research, particularly in studies aimed at overcoming resistance to radiation and improving therapeutic outcomes in tumorigenesis.

Cat. No.

A28961

CAS No.

374071-46-2

CEP-8983

CEP-8983 is a potent inhibitor of PARP-1 and PARP-2, with IC50 values of 20 nM and 6 nM, respectively. This compound effectively enhances the sensitivity of chemotherapy-resistant cell lines and subcutaneous xenograft models to the anticancer agents Temozolomide and Camptothecin. Its ability to disrupt DNA repair mechanisms makes CEP-8983 a valuable tool for cancer research, particularly in studies focusing on therapeutic resistance and combination therapies.

Cat. No.

A28962

CAS No.

1542067-20-8

ST7710AA1

ST7710AA1 is a potent inhibitor of PARP-1, exhibiting an IC50 value of 0.07 µM. This compound demonstrates significant antiproliferative and anticancer activity, making it a valuable tool for research in oncology and cellular biology. Its ability to inhibit PARP-1 can be leveraged to explore mechanisms of cancer cell survival and the effects of DNA damage repair pathways.

Cat. No.

A28963

CAS No.

101494-95-5

8-Chloroquinazolin-4-ol

8-Chloroquinazolin-4-ol is a potent inhibitor of the PARP-1 enzyme, exhibiting an IC50 value of 5.65 μM. This compound serves as a nicotinamide mimic and plays a significant role in research focused on DNA repair mechanisms and cancer therapies. Its ability to modulate PARP-1 activity makes it a valuable tool for exploring therapeutic strategies in various disease models.

Cat. No.

A28964

CAS No.

53439-81-9

Benzo[c][1,8]naphthyridin-6(5H)-one

Benzo[c][1,8]naphthyridin-6(5H)-one is a potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1) and aurora kinase A, exhibiting IC50 values of 0.311 μM and 5.5 μM, respectively. This compound demonstrates low micromolar affinity for human adenosine receptors AR A1 and hA2A, with Ki values of 4.6 and 4.8 μM. Due to its mechanistic action, Benzo[c][1,8]naphthyridin-6(5H)-one is valuable for research applications targeting DNA repair pathways and cancer therapies.

Cat. No.

A28966

CAS No.

142404-10-2

BSI-401

BSI-401 is an orally active inhibitor of PARP-1, a key enzyme involved in DNA repair processes. This compound demonstrates significant anti-cancer activity, particularly in pancreatic cancer, both as a monotherapy and in combination with Oxaliplatin. BSI-401 is valuable for research into therapeutic strategies targeting DNA damage response pathways in cancer treatment.

Cat. No.

A28968

CAS No.

370872-09-6

UPF-1035

UPF-1035 is a selective inhibitor of PARP-2, exhibiting an IC50 value of 0.15 μM. This compound has been shown to increase CA1 pyramidal cell loss in the hippocampus, indicating its role in neuroprotection. UPF-1035 can be utilized in research focused on neurodegenerative diseases and the mechanisms of neuronal cell survival.

Cat. No.

A28971

CAS No.

1460285-69-1

Tankyrase-IN-5

Tankyrase-IN-5 is a potent inhibitor of tankyrase proteins TNKS1 and TNKS2, demonstrating IC50 values of 2.3 nM and 7.9 nM, respectively. This compound can effectively disrupt the poly(ADP-ribosyl)ation process, influencing various cellular functions and signaling pathways. It is primarily used in research related to cancer biology and cellular regulation, offering valuable insights into the role of tankyrases in disease mechanisms.

Cat. No.

A28972

CAS No.

2756337-27-4

PARP1-IN-19

PARP1-IN-19 is a potent inhibitor of poly (ADP-ribose) polymerase 1 (PARP1), a key enzyme involved in DNA repair mechanisms. This compound exhibits significant antitumor activity, making it a valuable tool in cancer research and therapeutic development. It is primarily utilized in studies focusing on the modulation of DNA damage response pathways and the exploration of combination therapies in oncology.