PARP

Cat. No.

A10111

CAS No.

763113-22-0

Olaparib (AZD2281)

Synonyms: KU-0059436; AZD2281

Olaparib (AZD2281) is an inhibitor of poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair.

Cat. No.

A11026

CAS No.

1038915-60-4

Niraparib (MK-4827)

Synonyms: MK4827

MK-4827 is a novel potent, orally bioavailable PARP-1 and PARP-2 inhibitor.

Cat. No.

A10994

CAS No.

284028-89-3

XAV 939

XAV 939 is a TNKS inhibitor (IC50 values are 0.011 and 0.004 μM for TNKS1 and TNKS2 respectively).

Cat. No.

A10026

CAS No.

912444-00-9

Veliparib (ABT-888)

Synonyms: ABT-888

ABT-888(Veliparib) is a potential anti-cancer drug acting as a PARP inhibitor.

Cat. No.

A10045

CAS No.

459868-92-9

Rucaparib (AG-014699) phosphate

Synonyms: PF-01367338; AG-014447 (as free base)

AG-014699 (Rucaparib) is a PARP inhibitor that inhibits poly(ADP-ribose) polymerase (PARP) is a key enzyme in DNA repair.

Cat. No.

A11243

CAS No.

1207456-01-6

Talazoparib (BMN673)

Synonyms: BMN-673; LT-673

BMN-673 is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity.

Cat. No.

A12665

CAS No.

344458-15-7

PJ 34 hydrochloride

Synonyms: PJ34

PJ 34 hydrochloride is a potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC50 = 20 nM).

Cat. No.

A10046

CAS No.

328543-09-5

AG14361

AG14361 is a potent PARP inhibitor, enhanced TMZ cytotoxicity in MMR(mismatch repair)-proficient / deficient cells.

Cat. No.

A10164

CAS No.

160003-66-7

Iniparib (BSI-201)

Synonyms: NSC-746045; IND-71677; BSI-201

BSI-201 is a potent inhibitor of PARP-1 and has been shown to cross the blood-brain barrier.

Cat. No.

A10475

CAS No.

3544-24-9

3-Aminobenzamide

Synonyms: 3-AB

3-Aminobenzamide is a novel PARP inhibitor, known to sensitize cells to radiation in vitro by inhibiting the repair of DNA damage.

Cat. No.

A14182

CAS No.

283173-50-2

Rucaparib

Synonyms: AG-014699; PF-01367338

Rucaparib is a potent inhibitor of purified full-length human PARP-1 and shows higher inhibition of cellular PARP in LoVo and SW620 cells.

Cat. No.

A15215

CAS No.

344458-19-1

PJ34

PJ34 is a novel potent specific inhibitor of PARP-l/2 with EC50 of 20 nM.

Cat. No.

A15528

CAS No.

1380672-07-0

G007-LK

G007-LK displays high selectivity toward tankyrases 1 and 2 with biochemical IC50 values of 46 nM and 25 nM, respectively, and a cellular IC50 value of 50 nM combined with an excellent pharmacokinetic profile in mice,

Cat. No.

A16618

CAS No.

1038915-73-9

Niraparib tosylate

Synonyms: MK-4827 tosylate

Niraparib tosylate (MK-4827 tosylate) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with an IC50 of 3.8 and 2.1 nM, respectively.

Cat. No.

A20238

CAS No.

1373431-65-2

Talazoparib tosylate

Synonyms: BMN 673ts

Talazoparib tosylate (BMN 673ts) is a novel, potent and orally available PARP1/2 inhibitor with an IC50 of 0.57 nM for PARP1.

Cat. No.

A20680

CAS No.

501364-82-5

INO-1001

Synonyms: IN01001

INO-1001 is a potent and selective poly (ADP-ribose) polymerase (PARP) inhibitor.

Cat. No.

A10019

CAS No.

934162-61-5

A-966492

A-966492 displayed high potency against the poly(ADP-ribose) polymerase-1 (PARP-1) enzyme with a K(i) of 1 nM and an EC(50) of 1 nM in a whole cell assay.

Cat. No.

A11454

CAS No.

865565-29-3

TC-E 5001

TC-E 5001 is dual tankyrase (TNKS) inhibitor (Kd values are 79 and 28 nM for TNKS1 and TNKS2 respectively, IC50 = 33 nM for TNKS2) that is devoid of activity at PARP1 and PARP2 (IC50 >19 uM). Inhibits Wnt signaling and stabilizes Axin2 levels.

Cat. No.

A12393

CAS No.

1174043-16-3

AZD-2461

AZD2461 is a novel and potent PARP inhibitor with lower affinity to P-glycoprotein.

Cat. No.

A12750

CAS No.

1048371-03-4

UPF 1069

UPF 1069 is a selective poly(ADP-ribose) polymerase (PARP) 2 inhibitor (IC50 values are 0.3 and 8.0 μM for PARP-2 and PARP-1 respectively).

Cat. No.

A13731

CAS No.

664993-53-7

JW 55

JW 55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2).

Cat. No.

A14283

CAS No.

838818-26-1

WIKI4

WIKI4 is a novel Tankyrase inhibitor with IC50 of 15 nM for TNKS2.

Cat. No.

A14309

CAS No.

1445251-22-8

ME0328

ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1.

Cat. No.

A14371

CAS No.

1315330-11-0

TAK1/MAP4K2 inhibitor 1

TAK1/MAP4K2 inhibitor 1 is a potent dual inhibitor targeting transforming growth factor β-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2), exhibiting IC₅₀ values of 41.1 nM and 18.2 nM, respectively.

Cat. No.

A15024

CAS No.

1207456-00-5

BMN-673 8R,9S

Synonyms: (8R,9S)-BMN-673

BMN-673 (8R,9S) is the (8R,9S) enantiomer of BMN-673. BMN 673 is a novel PARP inhibitor with IC50 of 0.58 nM.