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Cyclophilin

Cyclophilin inhibitors and ligands target cyclophilins, prolyl isomerases that bind cyclosporin A. Cyclophilin was identified in 1984 as the cytosolic protein that binds this immunosuppressant. In 1991 the cyclophilin and cyclosporin A complex was shown to inhibit the phosphatase calcineurin, which explains the immunosuppressive action. Alisporivir and NIM811 are cyclosporin analogs that bind cyclophilins but do not inhibit calcineurin. Cyclosporin C is a natural member of the cyclosporin family, and Cyclophilin inhibitor 1 is described as a cyclophilin A inhibitor. The set also includes RAS inhibitors such as RMC-7977 and elironrasib. These compounds form a tri-complex with cyclophilin A and active RAS, a mechanism reported in 2023.

2 Items

  • ERAS-0015
    Cat. No.
    A24223
    CAS No.
    3034673-92-9

    ERAS-0015 (Pan-RAS-IN-2)

    Synonyms: Pan-RAS-IN-2

    ERAS-0015 (Pan-RAS-IN-2) is a molecular glue that targets RAS by promoting the formation of ternary complexes with cyclophilin A (CYPA) and active RAS (ON) proteins. This interaction disrupts the binding of RAF to RAS, thereby inhibiting downstream signaling. Pan-rasin-2 exhibits significant antiproliferative activity in RAS-mutant cell lines and shows promise as an anti-tumor agent.

    In stock View Details
    5 mg
    $378.00
    10 mg
    $651.00
    All 4 sizes
  • Acetyl-cyclosporin A aldehyde
    Cat. No.
    A81397
    CAS No.
    121584-52-9

    Acetyl-cyclosporin A aldehyde

    Acetyl-cyclosporin A aldehyde is a derivative of Cyclosporin A featuring an acetyl group and a reducing aldehyde moiety. This compound serves as a molecular glue by effectively inhibiting calmodulin and binding to cyclophilin, which can influence the nuclear translocation of NF-AT and may lead to mitochondrial damage. Its unique properties make it valuable for research applications aimed at understanding calcium signaling pathways and mitochondrial dynamics in various biological contexts.

    In stock View Details
    100 mg
    $25.00
    200 mg
    $35.00
    All 4 sizes

2 Items

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