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MHC

Major histocompatibility complex (MHC) research products include peptide antigens that MHC molecules present to T cells. Class I molecules display peptides from cytosolic proteins to cytotoxic T cells, whereas class II molecules present to helper T cells. In 1974 virus-specific T cell killing was shown to require a shared MHC haplotype, known as MHC restriction. The 1987 crystal structure of human leukocyte antigen A2 (HLA-A2) revealed a peptide-binding groove between two α-helices. The chicken ovalbumin (OVA) epitope SIINFEKL is offered as OVA Peptide(257-264) TFA, a trifluoroacetate salt. It binds the mouse class I molecule H-2Kb and is used to stimulate ovalbumin-specific cytotoxic T cells. OVA (55-62) is a second ovalbumin peptide presented by H-2Kb in mouse T cell studies.

2 Items

  • FC-14369
    Cat. No.
    A51339
    CAS No.
    3066894-28-5

    FC-14369

    FC-14369 is a PROTAC degrader that selectively targets the HIV-1 Nef protein, exhibiting a DC50 value of 160 nM. By engaging both Nef and the Cereblon E3 ubiquitin ligase, FC-14369 facilitates the ubiquitination and subsequent proteasomal degradation of Nef, leading to the restoration of CD4 and MHC-I expression on the cell surface and effectively inhibiting HIV-1 replication. This compound is valuable for research focused on HIV infection and AIDS, advancing understanding of therapeutic strategies in viral infections.

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    1 mg
    $1,150.00
    5 mg
    $3,545.00
    All 3 sizes
  • FC-14367
    Cat. No.
    A51468
    CAS No.
    3066893-65-7

    FC-14367

    FC-14367 is a PROTAC degrader that selectively targets the HIV-1 Nef protein. It facilitates the formation of a ternary complex by simultaneously binding to Nef and Cereblon E3 ubiquitin ligase, leading to the ubiquitination and subsequent proteasomal degradation of Nef. This process restores the surface expression of CD4 and MHC-I molecules while effectively inhibiting HIV-1 replication. FC-14367 is valuable for research focused on HIV infection and AIDS pathogenesis.

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    Out of stock

    All 3 sizes

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