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Salt-inducible Kinase (SIK)

Salt-inducible kinase (SIK) inhibitors act on SIK1, SIK2 and SIK3, three related serine-threonine kinases. SIK1 was cloned from the adrenal glands of rats fed a high-salt diet, which gave the family its name. The kinases belong to the group related to adenosine monophosphate-activated protein kinase (AMPK). They phosphorylate CREB-regulated transcription coactivators (CRTCs) and class IIa histone deacetylases, keeping them in the cytoplasm. In macrophages, SIK inhibition with HG-9-91-01 lets CRTC3 enter the nucleus and shifts the cells toward a regulatory, interleukin-10-producing state. Other inhibitors in the section include YKL-05-099, the SIK2 inhibitor ARN-3236, GLPG3312 and MRT67307.

2 Items

  • DB0614
    Cat. No.
    A24447
    CAS No.
    2769753-47-9

    DB0614

    DB0614 is a PROTAC molecule utilizing a cereblon ligand, designed as a selective and potent degrader of NEK9 and other kinases. It induces the degradation of multiple kinases, including ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1–3, MAP4K5, MAPK14, MAPK7–9, MAPKAPK2/3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1/3, SIK2/3, STK35, TNK2, and ULK1. DB0614 is suitable for research involving diseases or disorders driven by aberrant kinase activity.

    In stock View Details
    1 mg
    $180.00
    5 mg
    $540.00
    All 4 sizes
  • DB1113
    Cat. No.
    A24837
    CAS No.
    2769753-53-7

    DB1113

    DB1113 is a bifunctional compound designed for targeted protein degradation of various kinases. It effectively induces degradation of ABL1, ABL2, BLK, CDK4, CDK11B, EPHA3, MAPK7, RIPK1, and others, facilitating the investigation of kinase-related signaling pathways. DB1113 is suitable for research focusing on diseases or disorders associated with dysregulated kinase activity, providing a valuable tool for exploring therapeutic interventions in cancer and other conditions.

    In stock View Details
    5 mg
    $695.00
    10 mg
    $1,220.00
    All 2 sizes

2 Items

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