NOD-like Receptor (NLR) | Adooq Bioscience

Cat. No.: A25175

CAS No.: 3069891-91-1

NEK7 degrader-1

NEK7 degrader-1 is a potent NEK7 degrader with a DC50 of 0.1 nM, specifically designed to modulate NF-kB signaling pathways. It effectively inhibits caspase-1 activity and reduces IL-1β release in macrophages upon NLRP3 inflammasome activation. This compound is applicable for research in autoinflammatory and autoimmune disorders, including multiple sclerosis, as well as neurodegenerative diseases like Alzheimer's disease, and metabolic disorders such as pericarditis and Type 2 diabetes.

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Cat. No.: A35615

CAS No.: 3081572-53-1

MC-ND-18

MC-ND-18 is an ATTEC degrader targeting NLRP3, functioning primarily through autophagic pathways. With a DC50 value of 125.5 nM in THP-1 cells, this compound facilitates the selective degradation of NLRP3. Composed of a ligand specific to NLRP3, a linker, and an LC3 ligand, MC-ND-18 is valuable for research investigating inflammation and diseases associated with NLRP3 activation.

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Cat. No.: A35626

CAS No.: 3037413-54-7

NEK7 degrader-2

NEK7 degrader-2 (Compound 25) is a targeted NEK7 degrader that facilitates dose-dependent degradation of NEK7 specifically in human PBMC-derived macrophages. This compound effectively reduces the release of pro-inflammatory cytokine IL-1β triggered by NLRP3 inflammasome activation. NEK7 degrader-2 serves as a valuable tool for investigating the mechanisms underlying inflammatory diseases.

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Cat. No.: A55080

CAS No.: 3119435-52-5

NEK7 degrader-3

NEK7 degrader-3 is an orally active NEK7 molecular glue degrader with a DC50 of 33.1 nM, which effectively mediates the interaction between NEK7 and the E3 ligase cereblon, leading to the proteasomal degradation of NEK7. This degradation process attenuates NLRP3 inflammasome-mediated inflammatory responses, resulting in the inhibition of caspase-1 activity and the release of pro-inflammatory cytokines IL-1β, IL-1α, and IL-18. NEK7 degrader-3 demonstrates significant anti-inflammatory effects in LPS-induced neuroinflammation mouse models, serving as a valuable tool for research focused on neuroinflammation.

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Cat. No.: A64899

CAS No.: 3110847-73-6

HDAC3 degrader-2

HDAC3 Degrader-2 is a selective degrader of histone deacetylase 3 (HDAC3), functioning through targeted degradation to inhibit the activation of the NLRP3 inflammasome. By facilitating the reduction of IL-1β maturation and caspase-1 activity, HDAC3 Degrader-2 demonstrates significant anti-inflammatory effects. This reagent is applicable in researching conditions such as endotoxin shock, colitis, and gouty arthritis, providing valuable insights into mechanisms of inflammation and therapeutic interventions.

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