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Toll-like Receptors

Toll-like receptor (TLR) agonists and inhibitors act on pattern recognition receptors of the innate immune system. A human homologue of the Drosophila Toll protein was shown in 1997 to signal activation of adaptive immunity. Each TLR recognizes particular microbial molecules, and mutations in mouse Tlr4 identified TLR4 as essential for lipopolysaccharide (LPS) signaling. The imidazoquinolines imiquimod and resiquimod activate immune cells through TLR7 and the adaptor myeloid differentiation primary response 88 (MyD88). Further agonists include GS-9620 for TLR7 and VTX-2337 for TLR8. Resatorvid and TLR2-IN-C29 inhibit TLR4 and TLR2 signaling, respectively, for studies of inflammation and host defense.

1 Item

  • DB-3-291
    Cat. No.
    A24829
    CAS No.
    2769753-64-0

    DB-3-291

    DB-3-291 is a potent and selective PROTAC degrader targeting the protein CSK, exhibiting a Kd of 1 nM. This compound facilitates the degradation of CSK through its specific interaction with the E3 ligase, enabling in-depth studies of CSK-related biological pathways and providing insights into potential therapeutic strategies. It is valuable for researchers investigating targeted protein degradation and cancer biology.

    In stock View Details
    5 mg
    $260.00
    10 mg
    $430.00
    All 5 sizes

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