Purinergic (P2Y) Receptors

Cat. No.

A62876

CAS No.

79049-97-1

Uridine-5'-O-(3-thiotriphosphate)

Synonyms: UTPγS

Uridine-5'-O-(3-thiotriphosphate) (UTPγS) is a stable analogue of Uridine triphosphate (UTP) that acts as a potent agonist for the P2Y2 and P2Y4 receptors. It demonstrates significant biological activity by stimulating inositol phosphate formation in human 1321N1 astrocytoma cells that express the phospholipase C-coupled human P2U-purinoceptor, with an EC50 value of 240 nM. This compound is valuable for research applications focused on purinergic signaling and receptor pharmacology.

Cat. No.

A62892

CAS No.

528-04-1

UDP-GlcNAc

Synonyms: UDP-N-Acetyl-D-glucosamine; Uridine diphospho-N-acetylglucosamine; UDP-N-acetylglucosamine

UDP-GlcNAc serves as a full agonist of the P2Y14 receptor, a key mediator in various cellular signaling pathways. It plays a crucial role in inhibiting adenosine 3',5'-monophosphate (cAMP) formation, providing insight into metabolic processes and receptor signaling. This compound is particularly valuable in research related to bacterial infections and the study of peptidoglycan biosynthesis.

Cat. No.

A62896

CAS No.

221010-51-1

Uridine 5'-O-thiodiphosphate

Synonyms: UDP-β-S

Uridine 5'-O-thiodiphosphate (UDP-β-S) is a stable analog of uridine diphosphate that selectively acts as an agonist for the P2Y6 receptor. This compound exhibits enhanced metabolic stability, making it valuable for investigating signaling pathways related to cardiovascular diseases. Its application in research provides insights into P2Y6 receptor-mediated processes, contributing to the understanding of cellular responses and potential therapeutic targets.

Cat. No.

A62897

CAS No.

43170-89-4

2-MeS-ATP

Synonyms: 2-Methylthio-ATP

2-Methylthio-ATP (2-MeS-ATP) is an agonist of the P2Y purinergic receptor, specifically designed for adenosine nucleotide modulation. This compound demonstrates key biological activity by inhibiting the release of inflammatory mediators from macrophages in response to lipopolysaccharide (LPS) stimulation. 2-MeS-ATP is a valuable tool for research into endotoxin shock and various inflammatory disorders, providing insights into purinergic signaling and its therapeutic potential.

Cat. No.

A62899

CAS No.

35763-29-2

2-Thio-UTP

2-Thio-UTP is a selective P2Y2 agonist exhibiting an EC50 value of 50 nM. It has demonstrated the ability to reduce pro-fibrotic gene expression and protein levels of α-smooth muscle actin. This reagent is valuable for research applications related to calcific aortic valve stenosis (CAVS) and other fibrotic disorders.

Cat. No.

A62900

CAS No.

15548-52-4

5'-UMPS

Synonyms: Uridine-5'-O-monophosphorothioate

5'-UMPS (Uridine-5'-O-monophosphorothioate) acts as an agonist of the P2Y14 receptor. This compound has been shown to slightly induce growth in HeLa cells, highlighting its potential role in cellular proliferation studies. As a valuable tool in pharmacological research, 5'-UMPS may contribute to the understanding of purinergic signaling pathways and their biological implications.

Cat. No.

A62904

CAS No.

68507-49-3

4-Thiouridine 5′-triphosphate tetrasodium

Synonyms: 4-Thio-UTP tetrasodium

4-Thiouridine 5′-triphosphate tetrasodium is a potent agonist of the P2Y2 and P2Y4 receptors, exhibiting EC50 values of 35 nM and 350 nM, respectively. This UTP analog is suitable for various research applications, including cross-linking experiments and transcriptional complex labeling studies, making it a valuable tool for investigating purinergic signaling pathways.

Cat. No.

A62907

CAS No.

3033550-04-5

MRS2905 trisodium

Synonyms: a,β-Methylene-2-thio-UDP trisodium

MRS2905 trisodium is a selective agonist for the P2Y14 receptor, exhibiting an EC50 of 0.92 nM. This compound demonstrates a lack of activity at the UDP-activated P2Y6 receptor and other P2Y receptor subtypes. MRS2905 trisodium is a valuable tool for researchers studying purinergic signaling and its implications in various biological processes and disease states.

Cat. No.

B21646

CAS No.

58-98-0

Uridine 5'-diphosphate

Synonyms: UDP

Uridine 5'-diphosphate (UDP) serves as a potent agonist for the P2Y6 receptor, exhibiting an EC50 value of 0.013 μM for the human variant of this receptor. UDP plays a critical role in various biological processes, including inflammation and immune response modulation. Its application in research encompasses the study of purinergic signaling pathways and their implications in cellular communication and function.