P2X Receptor

Cat. No.

A67883

CAS No.

1343364-54-4

α,β-Methylene-ATP trisodium

α,β-Methylene-ATP trisodium is a potent agonist of P2X3 and P2X7 receptors, which facilitates significant biological responses through purinergic receptor activation. This compound is capable of traversing the blood-brain barrier, thereby influencing both peripheral and central nervous system pathways. It is instrumental in studying reflex cardiovascular responses and antinociceptive mechanisms mediated by noradrenergic neurons in the locus coeruleus. Researchers utilize α,β-Methylene-ATP trisodium for insights into neuropathic pain mechanisms and cardiovascular reflex regulation.

Cat. No.

A67902

CAS No.

100020-57-3

2-Methylthio-ATP tetrasodium

2-Methylthio-ATP tetrasodium is a non-specific P2-receptor agonist that modulates purinergic signaling pathways. It has been shown to cause noncompetitive inhibition of ADP-induced aggregation in human platelets. This reagent is valuable for studies investigating platelet function, receptor signaling, and related cardiovascular research applications.

Cat. No.

A67907

CAS No.

112898-15-4

BzATP triethylammonium

Synonyms: Benzoylbenzoyl-ATP triethylammonium

BzATP triethylammonium is a potent P2X receptor agonist that exhibits varying pEC50 values across multiple P2X receptor subtypes, including 8.74 for P2X1, 5.26 for P2X2, 7.10 for P2X3, 7.50 for P2X2/3, 6.19 for P2X4, and 6.31 for P2X7. It demonstrates significant activity at P2X7 receptors, with EC50 values of 3.6 μM for rat P2X7 and 285 μM for mouse P2X7. BzATP triethylammonium is valuable for research investigating purinergic signaling pathways and receptor pharmacology.

Cat. No.

A67927

CAS No.

23567-97-7

8-Bromo-ATP

Synonyms: 8-Bromoadenosine 5'-triphosphate; 8-Br-ATP

8-Bromo-ATP, an ATP analogue, serves as a potent agonist for purinergic P2X receptors. This compound demonstrates cytotoxic effects on multiple myeloma cells, with an IC50 value of 23.1 μM, highlighting its potential for cancer research. 8-Bromo-ATP is useful in studies investigating purinergic signaling and its implications in tumor biology.

Cat. No.

A67933

CAS No.

7292-42-4

α,β-Methylene-ATP

α,β-Methylene-ATP is a selective agonist of the P2X1 and P2X3 receptors, capable of crossing the blood-brain barrier. Its activation of P2X receptors induces a reflex pressor response associated with the peripheral muscles and the central locus coeruleus, while engaging noradrenergic neurons that mediate antinociceptive effects. α,β-Methylene-ATP is a valuable tool for investigating neuropathic pain mechanisms, cardiovascular reflex regulation, and the central nervous system's antinociceptive pathways.

Cat. No.

A67938

CAS No.

104809-20-3

α,β-Methylene-ATP dilithium

α,β-Methylene-ATP dilithium is a selective agonist for P2X1 and P2X3 receptors, capable of crossing the blood-brain barrier. It induces a reflex pressor response by activating these receptors in peripheral muscles and the central locus coeruleus, with effects that can be inhibited by the P2X antagonist PPADS. Additionally, it stimulates noradrenergic neurons in the central locus coeruleus, contributing to antinociceptive effects that can be reduced by DSP-4. This compound is valuable for investigating the mechanisms underlying neuropathic pain, cardiovascular reflex regulation, and central nervous system analgesia.

Cat. No.

A71289

CAS No.

4097-04-5

Diadenosine pentaphosphate (pentasodium)

Diadenosine pentaphosphate (pentasodium) is an agonist and negative modulator of the P2X1 receptor, an important endogenous purine dinucleotide primarily sourced from platelets. This compound is known to negatively regulate dendritic growth and branching by activating both homologous and heterologous P2X1 receptors, resulting in a modest transient increase in intracellular calcium levels in dendritic growth cones. Diadenosine pentaphosphate demonstrates selective inhibition of dendrite growth in cultured hippocampal neurons while leaving axon growth unaffected. Its presence in secretory vesicles such as platelets and brain synaptosomes highlights its biological relevance in neurophysiological studies.