Impurities & Reference Standards

Cat. No.

B10871

CAS No.

1037624-76-2

(R)-Bemcentinib

Synonyms: (R)-R428; (R)-BGB324

(R)-Bemcentinib, the R-isomer of Bemcentinib (R428), is a selective inhibitor of the Axl receptor tyrosine kinase, exhibiting an IC50 of 14 nM. This compound has demonstrated significant potential in inhibiting tumor metastasis and extending survival in preclinical models of metastatic breast cancer. Its application in cancer research underscores its importance in studying targeted therapies that disrupt Axl signaling pathways.

Cat. No.

B10958

CAS No.

1983928-04-6

(Rac)-GK563

(Rac)-GK563 is an isomer of GK563, serving as a selective inhibitor of Ca2+-independent group VI phospholipase A2 (GVIA iPLA2). This compound demonstrates potent biological activity by modulating lipid metabolism and influencing inflammatory pathways. It is applicable in research focused on studying lipid signaling mechanisms and disorders related to phospholipase activity.

Cat. No.

B10966

CAS No.

1798008-25-9

3'-(2-Fluorophenyl) ezetimibe

3'-(2-Fluorophenyl) ezetimibe is an isomer of the cholesterol transport inhibitor Ezetimibe, targeting the Niemann-Pick C1-like 1 (NPC1L1) protein. This compound is utilized in research focused on cholesterol absorption mechanisms and the development of therapeutic agents for hyperlipidemia. Its chemical structure allows for detailed studies of isomer-specific biological activities and interactions, aiding in the optimization of cholesterol-lowering treatments.

Cat. No.

B10968

CAS No.

67209-94-3

(S)-Isomyosmine

(S)-Isomyosmine is the S-enantiomer of Isomyosmine, a known inhibitor of nitrate reductase. This nicotine-derived alkaloid is primarily found in solanaceous plants that contain nicotine. (S)-Isomyosmine is utilized in research exploring its effects on inflammation and age-related disorders, potentially offering insights into therapeutic applications in these areas.

Cat. No.

B10972

CAS No.

229639-54-7

R-(+)-Mono-desmethylsibutramine

R-(+)-Mono-desmethylsibutramine is the R enantiomer of Mono-desmethylsibutramine, functioning primarily as a selective serotonin and norepinephrine reuptake inhibitor. This compound demonstrates potential in obesity management and metabolic research by influencing energy expenditure and appetite regulation. It is valuable for studies exploring the pharmacological effects of serotonin modulation on behavior and weight loss therapies.

Cat. No.

B18075

CAS No.

259200-30-1

(2R,3S)-Brassinazole

(2R,3S)-Brassinazole is a selective inhibitor of brassinosteroid biosynthesis. This enantiomer significantly disrupts seedling morphology, leading to deformations that resemble the characteristics of brassinosteroid-deficient mutants. In particular, exposure to (2R,3S)-Brassinazole induces dwarfism in cress and alters leaf morphology, including a pronounced downward curl and a dark green phenotype akin to Arabidopsis brassinosteroid-deficient mutants. The effects of dwarfism can be reversed with the application of brassinosteroids at low concentrations, highlighting its utility in studying brassinosteroid functions and pathways in plant biology.

Cat. No.

B18306

CAS No.

1576239-29-6

Pitnot-2

Pitnot-2 is an inactive analog of the clathrin inhibitor Pitstop 2, designed to serve as a negative control in research. Its primary mechanism involves inhibition of clathrin-mediated endocytosis, allowing researchers to assess the specificity and functional effects of active compounds. This reagent is particularly useful in studies investigating cellular uptake mechanisms and the role of clathrin in various biological processes.

Cat. No.

B20039

CAS No.

2915618-92-5

(rac)-K20

(rac)-K20 is the racemic mixture of K20, a selective inhibitor of KRas G12C with an IC50 value of 1.16 µM. This compound exhibits notable antitumor activity, making it a valuable tool for cancer research. It is primarily utilized in studies involving KRas G12C mutations and their role in oncogenesis.