E3 Ligase Ligand-Linker Conjugates: VHL

Cat. No.: A80205

CAS No.: 3043895-40-2

Lenalidomide-C13-piperazine-Boc

Lenalidomide-C13-piperazine-Boc is an E3 ligase ligand-linker conjugate designed for the synthesis of PROTAC degraders, specifically NC-R17. This compound facilitates targeted protein degradation by connecting a ligand for E3 ligases to a protein of interest. Its application in PROTAC technology enables the modulation of protein levels, making it a valuable tool for researchers studying protein regulation and therapeutic degradation strategies.

View Details

Out of stock

All 3 sizes

Cat. No.: A80237

CAS No.: 3077918-53-4

DHFR-IN-5-amino-PEG3-C2-azido

DHFR-IN-5-amino-PEG3-C2-azido is an E3 ligase ligand-linker conjugate designed for the synthesis of BION106, a potent DHFR-TS PROTAC degrader. This compound exhibits significant anti-malarial activity, making it a valuable tool in research focused on targeted protein degradation and parasitic diseases. Its unique structure facilitates the development of innovative therapeutic approaches in the field of drug discovery and development.

View Details

Out of stock

All 3 sizes

Cat. No.: A80252

CAS No.: 2415256-18-5

Boc-A 410099.1 amide-alkylC4-amine

Boc-A 410099.1 amide-alkylC4-amine is a functionalized ligand for E3 ligase utilized in PROTAC (Proteolysis Targeting Chimera) technology. This compound features an IAP ligand coupled with an amide-alkylC4 linker, which includes a terminal amine suitable for effective conjugation with target protein ligands. Its design enables precise modulation of targeted protein degradation, making it valuable for research in targeted therapy development and mechanistic studies of protein turnover.

In stock View Details

All 3 sizes

Cat. No.: A80261

CAS No.: 2750072-14-9

CBP-IN-1 acid

CBP-IN-1 acid is an E3 ligase ligand-linker conjugate designed for the synthesis of PROTACs, including the potent CBP/p300 degrader, CBPD-268. This compound exhibits significant anti-cancer activity by facilitating the targeted degradation of CBP/p300 proteins. It serves as a valuable tool for researchers exploring targeted protein degradation and its implications in cancer therapies.

View Details

Out of stock

All 3 sizes

Cat. No.: A80285

CAS No.: 2850354-04-8

Thalidomide-PEG1-OTs

Thalidomide-PEG1-OTs is a conjugate designed as a ligand for E3 ligases, facilitating targeted protein degradation. This compound serves as a versatile building block for the synthesis of various targeted degradation compounds, including YD54. Its application in chemical biology and drug discovery makes it a valuable tool for investigating E3 ligase-mediated pathways.

View Details

Out of stock

All 3 sizes

Cat. No.: A80288

CAS No.: 2227423-33-6

Pomalidomide-CO-C5-azide

Pomalidomide-CO-C5-azide is a bioorthogonal ligand designed for E3 ligase interaction. This compound enables the synthesis of proteolysis-targeting chimeras (PROTACs), which demonstrate promising anticancer activity. It serves as a valuable tool for researchers developing targeted therapies that utilize the ubiquitin-proteasome system to selectively degrade oncogenic proteins.

In stock View Details

All 2 sizes

Cat. No.: A80357

CAS No.: 2736510-46-4

E3 ligase Ligand PG-piperidine-C2-OH

E3 ligase Ligand PG-piperidine-C2-OH is a conjugate designed for E3 ligase targeting, featuring a CRBN-based ligand linked to a piperidine moiety. This versatile linker compound serves as a crucial component in the synthesis of Proteolysis Targeting Chimeras (PROTACs), facilitating the targeted degradation of proteins. Its application in chemical biology research enables the precise modulation of protein levels, contributing to studies in cancer therapeutics and other disease areas.

View Details

Out of stock

All 3 sizes

Cat. No.: A80361

CAS No.: 2725906-48-7

KRAS G12C degrader-2

KRAS G12C degrader-2 is an E3 ligase ligand-linker conjugate that incorporates a CRBN-based ligand and a functional linker. This compound facilitates the development of PROTAC (proteolysis-targeting chimeras), enabling targeted degradation of KRAS G12C-mutant proteins. It is a valuable tool for researchers investigating the therapeutic potential of targeted protein degradation in cancer treatment.

View Details

Out of stock

All 3 sizes

Cat. No.: A80364

CAS No.: 2300178-66-7

Pomalidomid-C6-PEG3-butyl-N3

Pomalidomid-C6-PEG3-butyl-N3 is a crosslinker-E3 ligase ligand conjugate designed for click chemistry applications. This reagent features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and ring strain-promoted alkyne-azide cycloaddition (SPAAC) reactions. Pomalidomid-C6-PEG3-butyl-N3 serves as an essential building block for the development of proteolysis-targeting chimeras (PROTACs) and targeted protein degraders, facilitating advancements in targeted protein degradation research.

In stock View Details

All 1 sizes

Cat. No.: A80435

CAS No.: 2911613-55-1

E3 Ligase Ligand-linker Conjugate 109

E3 Ligase Ligand-linker Conjugate 109 is an E3 ligase ligand-linker conjugate designed for the synthesis of PROTAC SOS1 degrader. This compound facilitates targeted protein degradation, enabling researchers to investigate the therapeutic potential of protein modulation in cellular systems. Its utility in developing targeted degradation strategies makes it an essential tool for drug discovery and development research.

View Details

Out of stock

All 3 sizes