Reveromycin D is a bacterial metabolite derived from Streptomyces, known for its ability to inhibit EGF-induced mitogenic activity in Balb/MK cells. This compound exhibits pH-dependent antifungal activity against Candida albicans, with minimum inhibitory concentrations (MICs) of 2 μg/mL at pH 3 and >500 μg/mL at pH 7.4. Additionally, Reveromycin D demonstrates significant antiproliferative effects on KB and K562 cancer cell lines, with IC50 values of 1.6 and 1.3 μg/mL, respectively, making it valuable for research in cell signaling and cancer therapeutics.
Reveromycin D is a bacterial metabolite derived from Streptomyces, known for its ability to inhibit EGF-induced mitogenic activity in Balb/MK cells. This compound exhibits pH-dependent antifungal activity against Candida albicans, with minimum inhibitory concentrations (MICs) of 2 μg/mL at pH 3 and >500 μg/mL at pH 7.4. Additionally, Reveromycin D demonstrates significant antiproliferative effects on KB and K562 cancer cell lines, with IC50 values of 1.6 and 1.3 μg/mL, respectively, making it valuable for research in cell signaling and cancer therapeutics.
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