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Stem-cell behavior is governed by signaling networks that balance self-renewal, lineage commitment, proliferation, and tissue organization. Wnt/β-catenin, Hedgehog, Notch, and Hippo signaling are prominent regulators of these decisions, with outcomes determined by developmental stage and cellular context. These networks are studied in regeneration, organoid biology, development, and cell plasticity.
The taxonomy is organized around Wnt and β-catenin, Hedgehog and Gli, Notch and γ-secretase, and Hippo and YAP, with additional related regulatory targets and an organoid-focused group. These categories support pathway-specific investigation while acknowledging extensive cross-talk between developmental systems. Together, these groupings support pathway-specific studies while acknowledging extensive cross-talk among developmental signaling systems.
