β-catenin

Cat. No.

A44083

CAS No.

41475-27-8

C-Peptide 1 (rat)

C-Peptide 1 (rat) is a peptide that functions as an activator of β-catenin and GSK-3β. Its primary mechanism involves the regulation of the Wnt/β-catenin signaling pathway, which plays a crucial role in cellular processes such as proliferation and differentiation. C-Peptide 1 (rat) is utilized in cancer research, contributing to studies aimed at understanding tumorigenesis and potential therapeutic interventions.

Cat. No.

A44209

CAS No.

1053172-87-4

15-Oxospiramilactone

Synonyms: NC 043

15-Oxospiramilactone is a diterpene derivative that functions as a Wnt/β-catenin signaling inhibitor. It exhibits significant biological activity by suppressing tumorigenesis in colon cancer cells, making it a valuable reagent for cancer research. This compound is suitable for studies investigating the modulation of the Wnt pathway and its implications in colorectal cancer progression.

Cat. No.

A44231

CAS No.

877618-79-6

IWP-2-V2

IWP-2-V2 is an analogue of IWP-2 that effectively inhibits the Wnt/β-catenin signaling pathway. This compound plays a significant role in modulating cellular processes related to development and cancer, making it a valuable tool for researchers studying the implications of Wnt signaling in various biological contexts. Its ability to disrupt β-catenin-mediated transcriptional activity positions IWP-2-V2 as a potential candidate for investigations into regenerative medicine and cancer therapy.

Cat. No.

A44239

CAS No.

217317-45-8

21H7

21H7 is a selective inhibitor of the Wnt/β-catenin signaling pathway. This compound significantly inhibits cell proliferation in hair follicles and demonstrates potent growth suppression of breast and colon cancer cells. Due to its specific targeting of the Wnt/β-catenin pathway, 21H7 serves as a valuable tool in cancer research and therapeutic development.

Cat. No.

A44240

CAS No.

2952779-17-6

β-catenin-IN-7

β-Catenin-IN-7 is an inhibitor of β-catenin, specifically disrupting the interaction between β-catenin and Tcf-4. This compound effectively inhibits Wnt-dependent target gene expression, demonstrating significant anti-cancer activity. It is a valuable tool for research applications focused on cancer biology and the Wnt signaling pathway.

Cat. No.

A44245

CAS No.

491828-75-2

PMED-1

PMED-1 is a potent β-catenin inhibitor that effectively diminishes β-catenin activity in hepatoblastoma and various hepatocellular carcinoma (HCC) cell lines, exhibiting an IC50 range of 4.87 to 32 μM. This compound disrupts Wnt signaling by reducing the interaction between β-catenin and CREB binding protein, leading to the inhibition of cell proliferation. PMED-1 is a valuable tool for cancer research, particularly in studies focused on targeting aberrant Wnt signaling pathways.

Cat. No.

A44246

CAS No.

2131223-69-1

Wnt/β-catenin-IN-4

Wnt/β-catenin-IN-4 is a potent inhibitor of the Wnt/β-catenin signaling pathway. This compound effectively disrupts β-catenin-dependent transcription, making it a valuable tool for investigating the role of Wnt signaling in various biological processes. It is commonly utilized in cancer research, developmental biology, and studies related to stem cell differentiation.

Cat. No.

A54065

CAS No.

2250328-65-3

MAI-400

MAI-400 is an inhibitor of the APC-Asef interaction, exhibiting a Kd of 12 nM and an IC50 of 250 nM. This compound is valuable for research related to colorectal cancer, providing insights into the underlying mechanisms of tumorigenesis and cellular signaling pathways. Its specificity offers potential in studying the roles of APC-Asef interactions in cancer progression and therapeutic development.

Cat. No.

B21864

CAS No.

902167-39-9

β-Catenin modulator-9

β-Catenin modulator-9 is a potent modulator of β-Catenin that specifically inhibits the activity of the stable β-catenin pool, effectively disrupting the Wnt signaling pathway. This compound is applicable in cancer research, providing valuable insights into tumorigenesis and cellular signaling mechanisms. Its ability to regulate β-Catenin activity makes it a useful tool for investigating the role of the Wnt pathway in various biological contexts.