Search by product name, CAS, target or catalog number. Press Down Arrow to reach product suggestions, Tab to move between links, and Escape to close suggestions.
β-catenin inhibitors and activators act on the transcriptional coactivator at the center of canonical Wnt signaling. β-Catenin also links cadherins to the actin cytoskeleton, while its free signaling pool is constantly degraded. Wnt stimulation stabilizes β-catenin, which then enters the nucleus and binds T-cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors. FH535 suppresses β-catenin/TCF-dependent transcription and also antagonizes peroxisome proliferator-activated receptors γ and δ (PPARγ, PPARδ). ICG-001 and foscenvivint block β-catenin binding to CREB-binding protein (CBP), a coactivator named after cyclic adenosine monophosphate response element-binding protein (CREB). Astragaloside I and WAY-316606 act in the opposite direction, and WAY-316606 inhibits the extracellular Wnt antagonist secreted frizzled-related protein 1 (sFRP-1). Upstream modulators, such as porcupine and tankyrase inhibitors, are listed under Wnt.
Surbisiran is a small interfering RNA (siRNA) that functions as a β-catenin synthesis reducer. By inhibiting the synthesis of β-catenin, it exhibits antineoplastic activity, making it a valuable tool for cancer research. Surbisiran can be utilized to explore the role of β-catenin in various malignancies and investigate therapeutic strategies targeting this pathway.
Out of stock
All 3 sizes
SLD1121 is a potent agonist of the Wnt/β-catenin signaling pathway, specifically targeting LRP6 with an inhibition constant (Kd) ranging from 4.52 to 7.49 nM. By interacting with the intracellular domain of LRP6, SLD1121 stabilizes the receptor, enhances its nuclear translocation, and promotes its association with β-catenin, TCF4, or LEF1, leading to the upregulation of Wnt-regulated and stem cell-associated genes. Notably, SLD1121 facilitates the transition of hair follicles from the telogen to anagen phase in the mouse hair growth cycle, making it a valuable reagent for research focused on hair loss and regenerative medicine.
Out of stock
All 3 sizes
aStAx-35R is a stapled peptide that functions as a β-catenin antagonist targeting the nuclear form of β-catenin to disrupt Wnt signaling pathways. By competitively inhibiting the binding of β-catenin to TCF4, aStAx-35R effectively induces growth inhibition in Wnt-dependent cancer cell lines. This compound presents valuable potential for research applications focused on cancer biology and therapeutic strategies targeting the Wnt/β-catenin signaling pathway.
Out of stock
All 3 sizes
KP-6 is a polypeptide that acts as a Wnt/β-catenin signaling pathway inhibitor. By inhibiting TGF-β, KP-6 disrupts critical fibrotic signaling pathways in vivo, effectively reducing renal tissue damage and fibrotic progression. This compound holds promise for research focused on chronic kidney disease (CKD) and other fibrosis-related disorders, making it a valuable tool for studying disease mechanisms and potential therapeutic interventions.
Wnt/β-catenin-IN-5 is a potent inhibitor of the Wnt/β-catenin signaling pathway. This compound demonstrates significant inhibition of cell proliferation in HCT 116, SW480, and A549 cell lines, with IC50 values of 3.05 μM, 3.27 μM, and 34.91 μM, respectively. It serves as a valuable tool for research focused on cancer biology and the role of Wnt signaling in tumor development and progression.
Out of stock
All 3 sizes
β-Catenin inhibitory peptoid targets the β-catenin:TCF interaction, exhibiting an IC50 of 5.44 µM. This compound effectively inhibits Wnt signaling with an IC50 of 0.105 µM and androgen receptor signaling with an IC50 of 1.02 µM in prostate cancer cell lines. The peptoid significantly reduces cell proliferation, making it a valuable tool for research in cancer biology and therapeutic development.
Out of stock
All 3 sizes
Wnt/β-catenin-IN-3 is a potent inhibitor of the Wnt/β-catenin signaling pathway, demonstrating low micromolar GI50 values across various cancer cell lines. This compound induces G2/M cell cycle arrest by activating the p53-p21 pathway and promotes apoptotic cell death through both intrinsic and extrinsic mechanisms in colon cancer cells. It serves as a valuable tool for investigating the role of Wnt/β-catenin signaling in cancer biology and therapeutic applications.
Out of stock
All 3 sizes
β-catenin-IN-8 is a potent inhibitor of β-catenin, targeting the Wnt signaling pathway. This compound effectively reduces the levels of β-catenin and c-Myc proteins, leading to downregulation of Wnt-target genes such as Fgf20 and Sall4. β-catenin-IN-8 exhibits anti-cancer activity in colorectal cancer models and demonstrates favorable metabolic stability, making it a valuable tool for research into cancer biology and therapeutic strategies.
Out of stock
All 3 sizes
Synonyms: CY-101
Getacatetide is a peptide-based inhibitor of the Wnt/β-catenin signaling pathway. This compound is designed to interfere with the activation of Wnt target genes, making it a valuable tool for investigating the role of Wnt/β-catenin signaling in solid tumors. Getacatetide's ability to disrupt this pathway facilitates research into cancer biology and the development of potential therapeutic strategies.
Out of stock
All 3 sizes
β-Catenin modulator-5, a selective modulator of β-Catenin, exhibits potent activity in regulating this key signaling pathway involved in cell proliferation and differentiation. This compound, characterized by its oxazole and thiazole structure, is valuable for research applications focused on cancer biology, developmental processes, and tissue homeostasis. Its ability to effectively manipulate β-Catenin activity makes it a crucial tool for investigating Wnt signaling-related mechanisms in various biological systems.
Out of stock
All 3 sizes
β-Catenin modulator-3 is a selective modulator of β-Catenin, characterized by its unique oxazole and thiazole chemical structure. This compound demonstrates significant biological activity in regulating β-Catenin signaling pathways, making it a valuable tool for research in cancer biology and developmental studies. Its ability to modulate the Wnt/β-Catenin pathway positions it as a potential candidate for studies targeting various cancers and neurodegenerative diseases.
Out of stock
All 3 sizes
FRATtide is a peptide inhibitor targeting GSK-3, effectively disrupting the phosphorylation of Axin and β-catenin. By preventing the binding of GSK-3 to Axin, FRATtide modulates the Wnt signaling pathway, making it a valuable tool for research in cancer biology and developmental processes. This reagent is essential for studying mechanisms of β-catenin regulation and its implications in various diseases.
β-Catenin modulator-7 is a targeted modulator of β-catenin, primarily influencing its expression in the cytoplasm and nucleus of HCT-116 cells. This compound effectively inhibits GSK 3β phosphorylation, promoting nitric oxide release and thereby reducing cancer cell proliferation with an IC50 of 0.6-0.9 μM. β-Catenin modulator-7 is positioned for research applications in studying colon cancer and its associated signaling pathways.
Out of stock
All 3 sizes
NLS-StAx-h is a selective β-catenin inhibitor designed to disrupt Wnt signaling pathways. This cell-permeable, stapled peptide exhibits an IC50 of 1.4 μM, effectively blocking β-catenin-transcription factor interactions. NLS-StAx-h demonstrates potent anti-proliferative effects on cancer cells, making it a valuable tool for research in cancer biology and therapeutic applications targeting aberrant Wnt signaling.
Out of stock
All 3 sizes
β-Catenin modulator-4 is a selective modulator of the β-Catenin signaling pathway. It exhibits strong potency in regulating β-Catenin activity, making it valuable for studies of cellular processes such as proliferation and differentiation. This compound is particularly relevant for research on developmental biology, cancer, and tissue regeneration, where β-Catenin plays a critical role in signaling dynamics.
Out of stock
All 3 sizes
YW2036 is a potent inhibitor of the Wnt/β-Catenin signaling pathway, exhibiting an IC50 value of 637 nM. This compound has significant biological activity and is primarily utilized in research focused on colorectal cancer (CRC). Its role as a Wnt/β-Catenin inhibitor makes it a valuable tool for studies investigating the mechanisms underlying CRC progression and treatment approaches.
Synonyms: NSC 109268
BC21 (NSC 109268) is a β-catenin/Tcf4 inhibitor with an IC50 of 5 μM. It disrupts the interaction between β-catenin and Tcf4-derived peptides, thereby inhibiting β-catenin/Tcf4-mediated transcriptional activity. This compound is particularly valuable in cancer research, where aberrant β-catenin signaling plays a critical role in tumor progression.
Out of stock
All 3 sizes
hsBCL9CT-24 is a potent inhibitor of the Wnt/β-catenin signaling pathway, targeting β-catenin to modulate oncogenic processes. This compound has demonstrated significant anti-tumor activity by reactivating the anti-cancer immune response impaired by aberrant Wnt signaling. hsBCL9CT-24 is applicable in cancer research, particularly in studies exploring Wnt pathway inhibition and immune evasion in tumor microenvironments.
Out of stock
All 3 sizes
β-Catenin modulator-2 is a selective modulator of β-Catenin, primarily targeting the Wnt signaling pathway. This compound, characterized by its oxazole and thiazole structure, exhibits significant biological activity in regulating β-Catenin levels. It is suitable for research applications aimed at studying cellular processes involved in cancer, developmental biology, and tissue regeneration.
β-Catenin modulator-1 (IIa-650) is a potent modulator of β-Catenin, a crucial component in the Wnt signaling pathway. It demonstrates significant biological activity in the regulation of cell proliferation and differentiation, making it invaluable for cancer research. This compound is utilized to investigate β-Catenin's role in tumorigenesis and other related pathologies, providing insights into therapeutic strategies targeting this pathway.
Out of stock
All 3 sizes
1(R),2(S)-epoxy Cannabidiol is a potent inhibitor of the Wnt/β-catenin signaling pathway. This structural analogue of phytocannabinoids demonstrates significant biological activity, making it a valuable tool for research in neuroprotection. Its ability to modulate this critical pathway positions it as a promising candidate for studies focused on neuroprotective agents.
Synonyms: PKF118-774
Murayaquinone is a potent inhibitor of the β-catenin/Tcf4 complex, exhibiting an IC50 of 2.4 μM. This compound, derived from Streptomyces sp. AN140557, demonstrates significant nematicidal activity. It serves as a valuable tool for research applications focused on Wnt signaling pathways and their roles in developmental biology and cancer research.
β-Catenin modulator-8 is a small molecule that functions as a β-Catenin modulator, primarily targeting the Wnt signaling pathway. It exhibits significant potential in altering β-Catenin activity, making it a valuable tool for research in cancer biology. This compound can be utilized in studies aimed at understanding tumorigenesis, as well as in the development of therapeutic strategies targeting β-Catenin-related malignancies.
Sempervirine nitrate is a Wnt/β-catenin pathway inhibitor derived from the alkaloid Gelsemium elegans Benth. This compound exhibits significant anti-proliferative effects on hepatocellular carcinoma (HCC) cells and promotes apoptosis through modulation of the Wnt/β-catenin signaling cascade. Sempervirine nitrate is valuable for research into cancer biology and therapeutic approaches targeting HCC.
β-Catenin modulator IIa-661 is a selective modulator of β-catenin, targeting its activity and inhibiting the Wnt/wingless (wg) signaling pathway. This compound is instrumental in cancer research, providing insights into β-catenin's role in tumor progression and cellular signaling. Its application may aid in developing therapeutic strategies for cancers characterized by aberrant Wnt signaling.
