Tanshindiol C is an EZH2 inhibitor that competes with S-adenosylmethionine, demonstrating an IC50 of 0.55 μM for inhibiting methyltransferase activity. It activates Nrf2 and Sirtuin 1 (Sirt1) in macrophages, suggesting potential roles in oxidative stress response. Tanshindiol C exhibits anti-cancer properties and may serve as a valuable tool in research related to atherosclerosis and epigenetic regulation.
Tanshindiol C is an EZH2 inhibitor that competes with S-adenosylmethionine, demonstrating an IC50 of 0.55 μM for inhibiting methyltransferase activity. It activates Nrf2 and Sirtuin 1 (Sirt1) in macrophages, suggesting potential roles in oxidative stress response. Tanshindiol C exhibits anti-cancer properties and may serve as a valuable tool in research related to atherosclerosis and epigenetic regulation.
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