Glutamate (EAAT) Transporters

Cat. No.

A66565

CAS No.

894002-50-7

LDN-212320

Synonyms: LDN-0212320; OSU-0212320

LDN-212320 is a potent activator of the glutamate transporter GLT-1 (EAAT2), primarily functioning at the translational level. This compound is known to mitigate nociceptive pain by enhancing astroglial GLT-1 expression in both the hippocampus and anterior cingulate cortex. LDN-212320 is valuable in research focused on pain modulation and neuroprotection, offering insights into the role of glutamate transporters in neurological conditions.

Cat. No.

A66574

CAS No.

892415-28-0

EAAT2 activator 1

EAAT2 Activator 1 is a potent activator of the excitatory amino acid transporter 2 (EAAT2), a critical protein responsible for the clearance of glutamate from synaptic clefts. This compound enhances EAAT2 protein levels in a dose-dependent manner, promoting efficient glutamate uptake. EAAT2 Activator 1 is relevant for research applications aimed at understanding glutamatergic signaling and neuroprotection in various neurological disorders.

Cat. No.

A66577

CAS No.

130775-79-0

MS-153

MS-153 is a selective activator of glutamate transporters, facilitating the uptake of glutamate into neurons and glial cells. This compound exhibits neuroprotective properties, making it a valuable tool in the study of neurodegenerative diseases and excitotoxicity. Its ability to modulate glutamate levels in the synaptic cleft has implications for research into neurological disorders and potential therapeutic approaches.