Search by product name, CAS, target or catalog number. Press Down Arrow to reach product suggestions, Tab to move between links, and Escape to close suggestions.
Aquaporin inhibitors and activators target membrane channels that carry water across cell membranes. Aquaporins (AQPs) are tetrameric membrane proteins, and each subunit forms its own pore. In 1992, a red cell membrane protein now called aquaporin 1 (AQP1) made Xenopus oocytes highly permeable to water. A 2001 crystal structure of AQP1 showed how the pore admits water while excluding protons. Aristolactam I and TC AQP1 1 are listed as AQP1 inhibitors, and AqF026 as an AQP1 activator. AER-271 and nicotinanilide target AQP4, the main water channel of astrocytes. DFP00173, Z433927330 and RF03176 act on AQP3, AQP7 and AQP9, respectively. These three isoforms belong to the aquaglyceroporins, which also conduct glycerol.
AqF026 is an activator of aquaporin 1 (AQP1), enhancing the channel activity of human AQP1 in the Xenopus laevis oocyte system. This compound significantly improves osmotic water transport across the peritoneum in mouse models of peritoneal dialysis. AqF026 is a valuable tool for investigating mechanisms related to ultrafiltration failure in peritoneal dialysis research.
