We use analytics and advertising cookies, which you can accept or reject; see our privacy policy.

Current choice:

Piezo Channel

Piezo channel agonists and antagonists act on Piezo1 and Piezo2, mechanically activated cation channels. Both proteins were identified in 2010 as essential components of distinct mechanically activated currents in mammalian cells. Piezo1 responds to shear stress and membrane stretch in endothelial, red blood and epithelial cells, whereas Piezo2 mediates light touch and proprioception in sensory neurons. Yoda 1 was reported in 2015 as the first chemical activator of Piezo1, and later agonists listed here include Yoda2, Jedi2 and Yaddle1. Dooku1, an analog of Yoda 1, antagonizes Yoda 1-evoked Piezo1 activation and aortic relaxation. GsMTx4 is a spider venom peptide that inhibits several mechanosensitive channels and also appears under TRP Channel.

1 Item

  • Jedi2
    Cat. No.
    A67947
    CAS No.
    651005-90-2

    Jedi2

    Jedi2 is a selective activator of the Piezo1 ion channel, facilitating mechanotransduction in various physiological processes. It demonstrates a binding affinity (Kd) of 2770 μM for mouse Piezo1 proteins, enabling the study of Piezo1's role in cellular responses to mechanical stimuli. This compound is suitable for research applications investigating the physiological and pathological implications of Piezo1 activation in multiple biological systems.

    In stock View Details
    2 mg
    $25.00
    5 mg
    $40.00
    All 7 sizes

1 Item

Added to your cart

View Cart Checkout

    Loading...