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Monoamine Transporter

Monoamine transporter inhibitors block reuptake of dopamine, noradrenaline and serotonin into neurons or vesicles. Plasma membrane transporters for dopamine (DAT), noradrenaline (NET) and serotonin (SERT) clear released transmitter from the synapse. Mice lacking DAT show hyperlocomotion and no response to cocaine or amphetamine, which identified this transporter as their main target. Vanoxerine 2HCl and GBR 12783 dihydrochloride are selective dopamine uptake inhibitors. Milnacipran hydrochloride inhibits both serotonin and noradrenaline reuptake at the plasma membrane. Vesicular monoamine transporters (VMAT) load monoamines into synaptic vesicles and are inhibited by reserpine. GZ-793A is a more selective inhibitor of the VMAT2 isoform.

1 Item

  • Apigenin
    Cat. No.
    A10081
    CAS No.
    520-36-5

    Apigenin

    Synonyms: 4',5,7-Trihydroxyflavone; Apigenol; C.I. Natural Yellow 1

    Apigenin, found in many plants, is a natural product belonging to the flavone class that is the aglycone of several naturally-occurring glycosides. Apigenin acts as a monoamine transporter activator, one of the few chemicals demonstrated to possess this property. Apigenin is a ligand for central benzodiazepine receptors that competitively inhibited the binding of flunitrazepam with a Ki of 4μM, exerting anxiolytic and slight sedative effects.

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    5 mg
    $30.00
    10 mg
    $40.00
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