Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
3-O-Methyl Colterol-d9 is a deuterium-labeled analog of 3-O-Methyl Colterol. This stable isotope is utilized in analytical studies to track metabolic pathways and quantify interactions in biological systems. Its primary applications include pharmacokinetic studies and the investigation of drug metabolism, enhancing the understanding of biological processes involving beta-adrenergic receptors. -
Stable Isotope
Atenolol-d6 is a deuterium-labeled variant of the cardioselective β1-adrenergic receptor blocker, Atenolol. It exhibits a Ki of 697 nM at the β1-adrenoceptor in guinea pig left ventricle membranes. This stable isotope is instrumental in pharmacokinetic studies and research focused on hypertension and angina pectoris, allowing for improved metabolic tracing and analytical characterization in various biological assays. -
Stable Isotope
Desloratadine-d5 hydrochloride is a stable isotope-labeled derivative of Desloratadine hydrochloride, designed for use in quantitative mass spectrometry applications. This compound retains the pharmacological properties of the parent drug while providing a valuable tool for understanding drug metabolism and pharmacokinetics. It is particularly suitable for research in allergology and histamine receptor studies, facilitating the assessment of drug interactions and efficacy in various biological systems. -
Lipid
(−)-11-hydroxy-Δ8-THC is a phytocannabinoid that acts primarily as a cannabinoid receptor inhibitor. This compound exhibits significant biological activity in modulating lipid signaling pathways. It is utilized in research applications focused on neuropharmacology and the therapeutic potential of cannabinoids in various medical conditions.
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Stable Isotope
(Rac)-Ambrisentan-d5 is a deuterium-labeled form of (Rac)-Ambrisentan, functioning primarily as a selective endothelin receptor antagonist. Its key biological activity includes inhibition of endothelin-1, a peptide known to play a crucial role in vasoconstriction and blood pressure regulation. This stable isotope is particularly useful in pharmacokinetic studies, allowing for precise tracking of drug metabolism and distribution in biological systems. -
Stable Isotope
Apomorphine hydrochloride-d4 is a deuterium-labeled derivative of Apomorphine hydrochloride, designed as a stable isotope for metabolic studies. This compound serves as a valuable tool in pharmacokinetic and drug metabolism research, enabling precise tracking of Apomorphine in biological systems. Its application extends to studies on dopamine receptor modulation and related neurological pathways, facilitating a deeper understanding of dopaminergic signaling and its implications in various disorders. -
Stable Isotope
trans-Dihydro Tetrabenazine-d7 is a deuterium-labeled stable isotope of (2S,3S,11bS)-3-Isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-ol. It serves as a valuable tool for isotopic labeling in biochemical research. Its distinct mass characteristics facilitate studies on pharmacokinetics, metabolism, and drug interactions, particularly in the context of neuropharmacology and the investigation of dopamine receptors. -
Stable Isotope
Labetalol hydrochloride-d5 is a deuterium-labeled form of Labetalol hydrochloride, specifically designed as a stable isotope for research applications. This compound functions as a selective α1-adrenergic and non-selective β-adrenergic receptor antagonist, primarily utilized for its antihypertensive properties. It is suitable for studying cardiovascular conditions, including hypertension, especially in contexts such as pregnancy where blood pressure regulation is critical. The stable isotope labeling facilitates advanced pharmacokinetic and metabolic studies. -
Stable Isotope
N-Pentylindole-d11 is a deuterated analogue of 1-Pentyl-1H-indole, serving as a stable isotope. This compound is particularly valuable in pharmacokinetic studies, as it aids in tracing the metabolic pathways of indole-based compounds. Its application extends to the analysis of drug metabolism and the study of cannabinoid receptors, enhancing the understanding of biological mechanisms in related research fields. -
Stable Isotope
1-Oxo Colterol-d9 is a deuterium-labeled analog of 2-(Tert-butylamino)-1-(3,4-dihydroxyphenyl)ethan-1-one, serving as a stable isotope standard. This compound is valuable for quantitative mass spectrometry applications in biochemical research, particularly in studies involving adrenergic receptor signaling and pharmacokinetics. Its incorporation of deuterium enables precise tracking and analysis of metabolic pathways, enhancing the understanding of drug metabolism and activity. -
Stable Isotope
5'-Hydroxyphenyl carvedilol-d5 is a stable isotope-labeled analogue of carvedilol, targeting beta-adrenergic receptors. This deuterated compound is useful in pharmacokinetic studies, enabling the tracing of metabolic pathways and the assessment of drug disposition in various biological systems. Its structural modifications enhance the sensitivity and accuracy of analytical methods, making it an essential reagent for research applications in cardiovascular pharmacology and drug development. -
Stable Isotope
rac-Rotigotine-d3 methyl ether is a deuterium-labeled analogue of the dopamine agonist rotigotine, targeting dopamine D2 and D3 receptors. This stable isotope is primarily utilized in pharmacokinetic studies and metabolic research, enabling precise tracking of rotigotine's distribution and metabolism in biological systems. Its application enhances the understanding of dopamine receptor activity and drug interactions. -
Adrenergic Receptor Antagonist
Yohimbine-d3 is a deuterated derivative of Yohimbine, functioning as an adrenergic receptor antagonist. This compound is utilized in research to study the modulation of adrenergic signaling pathways, specifically the alpha-2 adrenergic receptors. Its applications include investigations into the effects of adrenergic blockade on physiological processes and the potential therapeutic roles in conditions such as depression and sexual dysfunction. -
Stable Isotope
Dexmedetomidine-d4 L-tartrate (-d4-major) is a deuterium-labeled derivative of Dexmedetomidine L-tartrate, serving as a stable isotope for research applications. This compound is primarily utilized in pharmacokinetic studies and metabolic labeling, enabling accurate tracking of drug disposition and action mechanisms. It supports investigations into alpha-2 adrenergic receptor modulation and sedation research, providing insights into the pharmacological properties of its parent compound. -
Stable Isotope
1H-1-Ethyl-d5 Candesartan is a deuterium-labeled derivative of 1H-1-Ethyl Candesartan, primarily utilized as a stable isotope. This compound is valuable in pharmacokinetic studies, allowing for precise tracking of drug metabolism and distribution. It aids researchers in understanding the metabolic pathways and interactions of angiotensin receptor antagonists in cardiovascular studies. -
Stable Isotope
(R)-(+)-Celiprolol-d9 hydrochloride is a deuterium-labeled analogue of the racemic beta-blocker Celiprolol, primarily targeting beta-adrenergic receptors. This stable isotope derivative facilitates precise pharmacokinetic studies and isotopic labeling experiments in chemical research. Its unique properties make it suitable for applications in metabolomics, drug metabolism, and tracer studies to elucidate the pharmacodynamics of beta-blockers. -
Stable Isotope
7-Benzyloxy-N-des[[2-(2-hydroxy)ethoxy]ethyl] Quetiapine-d8 is a deuterium-labeled derivative of Quetiapine, a psychopharmacological agent primarily targeting serotonin and dopamine receptors. This stable isotope is utilized in pharmacokinetic studies to accurately track drug metabolism and bioavailability. It serves as a valuable tool for researchers investigating the pharmacodynamics and pharmacogenomics of antipsychotic therapies. -
Stable Isotope
Chlorproethazine-d10 hydrochloride is a deuterium-labeled derivative of Chlorproethazine hydrochloride, functioning as a stable isotope. This compound is primarily utilized in pharmacokinetic studies and drug metabolism research, allowing for enhanced tracking and quantification in biological systems. Its incorporation of deuterium facilitates improved analytical precision in investigations involving the pharmacodynamics of antagonists at dopamine receptors. -
Stable Isotope
Anandamide-d4 is a deuterium-labeled derivative of Anandamide, which serves as a stable isotope standard for research applications. This compound is primarily utilized in studies investigating the endocannabinoid system and its physiological effects, enabling precise quantification in metabolic and pharmacokinetic analyses. It aids researchers in elucidating cannabinoid receptor interactions and the role of endocannabinoids in various biological processes. -
Drug Impurity
Atenolol impurity 8 is a structural impurity associated with Atenolol, a selective beta-1 adrenergic receptor blocker. This compound is crucial for analyzing the purity of Atenolol formulations and evaluating potential impacts on drug efficacy and safety. It serves as an important reference standard in the pharmaceutical industry for quality control and compliance in drug development and analysis. -
Drug Impurity
Tamsulosin impurity 21 is a chemical impurity associated with the drug Tamsulosin, which primarily targets the α1-adrenergic receptors. This impurity may serve as a valuable reference standard in the analysis of Tamsulosin formulations. Its identification is crucial for assessing the purity and quality of pharmaceutical products in drug development and quality control. -
Drug Impurity
Ropinirole impurity 3 is a characterized impurity associated with the dopamine receptor agonist Ropinirole. This compound is crucial for assessing the purity and quality of Ropinirole in pharmaceutical formulations. It aids in the development and validation of analytical methods required for regulatory compliance in drug manufacturing. -
Drug Impurity
Tamsulosin impurity 14 is a known impurity associated with the pharmaceutical compound Tamsulosin, primarily targeting alpha-1 adrenergic receptors. This impurity is significant for quality control and analytical studies in drug development, particularly in determining the purity and stability of Tamsulosin formulations. Its characterization is essential for compliance with pharmaceutical regulations and ensuring therapeutic efficacy. -
Drug Impurity
Fluphenazine decanoate impurity 8 is a known impurity associated with Fluphenazine decanoate, an antipsychotic medication primarily targeting dopamine receptors. This compound can be utilized in analytical research to evaluate the purity of pharmaceutical formulations and support drug development processes. Its presence may affect pharmacokinetics and pharmacodynamics, making it essential for quality control and safety assessments in therapeutic applications. -
Drug Impurity
Mirabegron impurity 4 is a chemical impurity associated with the drug Mirabegron, a beta-3 adrenergic receptor agonist. This impurity is important for assessing the purity and quality of Mirabegron formulations in pharmaceutical research. Its characterization is crucial for ensuring compliance with regulatory standards and for conducting stability studies in drug development. -
Racemate
(±)-Levomepromazine is a racemic mixture primarily targeting dopamine receptors. It exhibits notable antipsychotic activity, making it relevant for research in psychiatry and neuropharmacology. Its effects on neurotransmitter pathways are valuable for studying various psychiatric disorders and the mechanisms of psychotropic agents. -
Nantenine Isomer
(R)-Nantenine is the levorotatory isomer of Nantenine, with a high affinity and selectivity for the α1A adrenergic receptor. This compound effectively blocks the behavioral suppression associated with 3,4-methylenedioxymethamphetamine (MDMA). Research applications for (R)-Nantenine primarily involve the study of disorders linked to MDMA abuse, providing valuable insights into its neuropharmacological effects. -
Isomer of 5-Fluoro PB-22
5-Fluoro PB-22 6-hydroxyisoquinoline isomer is a structural isomer of the synthetic cannabinoid 5-Fluoro PB-22, acting primarily as a cannabinoid receptor agonist. This compound exhibits significant binding affinity for CB1 and CB2 receptors, contributing to its potential biological effects. It can be utilized in research applications aimed at investigating the biochemical pathways and pharmacological effects of synthetic cannabinoids. -
Isomer of 5-Fluoro PB-22
5-Fluoro PB-22 N-(3-fluoropentyl) isomer is a structural isomer of 5-Fluoro PB-22, targeting the cannabinoid receptors. This compound exhibits significant biological activity related to the modulation of cannabinoid receptor signaling pathways. It is primarily utilized in research applications exploring cannabinoid pharmacology, drug interaction studies, and the development of therapeutic agents targeting the endocannabinoid system. -
Isomer of 5-Fluoro PB-22
5-Fluoro PB-22 5-hydroxyisoquinoline isomer is a structural isomer of 5-Fluoro PB-22, targeting the cannabinoid receptors. This compound has been studied for its potential biological activities within the endocannabinoid system. It may be utilized in research related to neuropharmacology and the exploration of cannabinoid receptor modulation. -
Isomer of PB-22
PB-22 6-Hydroxyquinoline isomer is a structural isomer of the cannabinoid PB-22, which primarily acts on the cannabinoid receptors. This compound may exhibit similar biological activities related to modulation of the endocannabinoid system, potentially influencing pain, inflammation, and mood regulation. It is suitable for research applications in pharmacology, toxicology, and cannabinoid receptor studies. -
Isomer of PB-22
PB-22 7-Hydroxyquinoline isomer is a structural isomer of PB-22, a synthetic cannabinoid. This compound targets cannabinoid receptors and exhibits activity that may influence the endocannabinoid system. PB-22 7-Hydroxyquinoline isomer is primarily utilized in cannabinoid research to explore its pharmacological properties and potential therapeutic applications. -
Isomer of PB-22
PB-22 8-Hydroxyisoquinoline isomer is a structural isomer of the synthetic cannabinoid PB-22. This compound acts primarily on cannabinoid receptors, modulating various signaling pathways. Its unique structure may offer insights into cannabinoid research and the development of novel therapeutic agents targeting the endocannabinoid system. PB-22 8-Hydroxyisoquinoline isomer is suitable for biochemical assays and pharmacological studies exploring cannabinoid receptor interactions. -
Isomer of PB-22
PB-22 5-Hydroxyquinoline isomer is a structural isomer of PB-22, a synthetic cannabinoid. This compound exhibits biological activity related to cannabinoid receptor modulation, making it relevant for pharmacological studies in endocannabinoid signaling pathways. Research applications include investigating the effects of synthetic cannabinoids on neural activity and their potential therapeutic uses in pain management and other neuropsychiatric conditions. -
Isomer of PB-22
PB-22 6-Hydroxyisoquinoline isomer is a structural isomer of PB-22, a synthetic cannabinoid. This compound exhibits cannabinoid receptor activity, thereby influencing endocannabinoid signaling pathways. It is primarily utilized in research settings to study the pharmacological effects of cannabinoid compounds and their potential therapeutic applications. -
Isomer of 5-Fluoro PB-22
5-Fluoro PB-22 N-(4-fluoropentyl) isomer is a structural isomer of 5-Fluoro PB-22 that acts as a potent cannabinoid receptor agonist. This compound exhibits biological activities that may modulate cannabinoid signaling pathways, making it relevant for research in neuropharmacology and cannabinoid receptor biology. Its unique profile allows for investigations into the effects of synthetic cannabinoids on physiological and psychological processes. -
Isomer of PB-22
PB-22 5-Hydroxyisoquinoline isomer is a structural isomer of the cannabinoid PB-22, targeting cannabinoid receptors in the central nervous system. This compound exhibits potential neuropharmacological activity, making it suitable for research into cannabinoids and their effects on various biological processes. Its unique structure allows for the exploration of the functional relationships between different isomers and their associated biological activity in preclinical studies. -
Isomer of 5-Fluoro PB-22
5-Fluoro PB-22 6-hydroxyquinoline isomer is a structural isomer of 5-Fluoro PB-22, targeting cannabinoid receptors in the endocannabinoid system. This compound is utilized in research focused on cannabinoid receptor modulation and the investigation of its pharmacological effects. Its unique structure allows for the exploration of potential therapeutic applications and the study of receptor binding dynamics. -
Isomer of 5-Fluoro PB-22
5-Fluoro PB-22 7-hydroxyisoquinoline isomer is a structural isomer of 5-Fluoro PB-22, primarily known for its activity at cannabinoid receptors. This compound exhibits potential in studying the effects of structural variations on cannabinoid receptor function and related signaling pathways. It is applicable in research focused on pharmacology, neuroscience, and the characterization of synthetic cannabinoids. -
Isomer of PB-22
PB-22 7-Hydroxyisoquinoline isomer is a structural isomer of the cannabinoid PB-22. This compound exhibits potential biological activity by interacting with cannabinoid receptors, which play a crucial role in various physiological processes. Research applications include studies on cannabinoid receptor signaling and exploration of therapeutic effects in neurological and inflammatory disorders. -
α2-Adrenergic Receptors Agonist
Methyldopa, an α2-adrenergic receptor agonist, is a potent antihypertensive compound. Acting as a proagent, it is metabolized to α-Methylepinephrine within the central nervous system, contributing to its effects on blood pressure regulation. This compound is primarily utilized in research applications focused on cardiovascular physiology and the modulation of neurogenic control of vascular tone. -
β-Adrenergic Agonist
Ritodrine hydrochloride is a potent β-adrenergic agonist that primarily targets β-adrenergic receptors. It is recognized for its ability to relax uterine smooth muscle and is utilized in the research of preterm labor management. Ritodrine hydrochloride is valuable for studying the mechanisms of uterine contractions and the pharmacological intervention of premature delivery. -
β-Adrenergic Receptor Blocker
Sotalol hydrochloride is a non-selective β-adrenergic receptor blocker that exhibits potent antiarrhythmic activity. It is utilized in research focused on pediatric arrhythmias and demonstrates efficacy by blocking β-receptors and the potassium channel KCNH2. Additionally, Sotalol hydrochloride holds potential applications as an antiepileptic agent, facilitating further studies into its diverse pharmacological effects. -
Endothelin Receptor Antagonist
Sulfisoxazole is an orally active endothelin receptor antagonist primarily targeting endothelin receptor A (IC50 = 0.60 μM) and endothelin receptor B (IC50 = 22 μM). This sulfonamide antibacterial agent boasts an oxazole substituent, enhancing its pharmacological profile. Sulfisoxazole is notably effective in inhibiting breast cancer exosome release through its action on endothelin receptor A, making it relevant for cancer research and studies focused on exosome biology. -
CXCR Agonist
VUF11207 is a potent agonist of the CXCR7 receptor, demonstrating a high affinity with a pKi of 8.1. This compound effectively induces the recruitment of β-arrestin2, with an pEC50 value of 8.8, and promotes the subsequent internalization of CXCR7, with an pEC50 of 7.9. VUF11207 is valuable for research applications focused on CXCR signaling pathways and β-arrestin-mediated processes. -
Cannabinoid Receptor Agonist
β-Caryophyllene is a potent agonist of the cannabinoid receptor type 2 (CB2). This compound is known for its anti-inflammatory and analgesic properties, making it a valuable tool in research focused on pain management and the endocannabinoid system. Additionally, β-Caryophyllene can be used to explore therapeutic applications in various disease models, including neurodegeneration and immune response studies. -
5-HT/Norepinephrine Reuptake Inhibitor
Desvenlafaxine is a selective 5-HT and norepinephrine reuptake inhibitor, primarily targeting the serotonin transporter (hSERT) and norepinephrine transporter (hNET) with IC50 values of 47.3 nM and 531.3 nM, respectively. This orally active compound effectively penetrates the blood-brain barrier, making it applicable in the treatment of major depressive disorders. Additionally, Desvenlafaxine exhibits weak binding affinity to the human dopamine transporter, with 62% inhibition observed at 100 μM, which may have implications for its overall pharmacological profile. -
Dopamine Receptor Antagonist
Droperidol is a butyrophenone compound primarily acting as a dopamine receptor antagonist. It inhibits the activation of GABA(A) and neuronal nicotinic acetylcholine receptors (nAChR), demonstrating IC50 values of 12.6 nM and 5.8 μM, respectively. This compound exhibits notable anesthetic and sedative properties, making it useful in research related to neuropharmacology and anesthesiology. -
Dopamine Receptor Inhibitor
Fluphenazine dihydrochloride is a potent dopamine receptor antagonist primarily targeting dopamine D2 receptors in the mesolimbic, nigrostriatal, and tuberoinfundibular pathways. This phenothiazine derivative also exhibits the ability to inhibit neuronal voltage-gated sodium channels. Its key biological activities include the suppression of Methylphenidate-induced stereotyped behaviors and climbing in murine models. Fluphenazine dihydrochloride is widely utilized in research related to psychosis, diabetic peripheral neuropathy, and may also have implications for the inhibition of SARS-CoV-2. -
β-Adrenergic Antagonist
Levobetaxolol hydrochloride is a selective β-adrenergic antagonist primarily used in the treatment of ocular hypertension. This compound effectively reduces intraocular pressure, making it valuable for research related to glaucoma and other eye disorders. Investigations into its pharmacological profile can advance understanding of adrenergic receptor modulation in ocular applications.
