IAP

Cat. No.

A11928

CAS No.

1005342-46-0

LCL-161

LCL161 is an orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity.

Cat. No.

A15800

CAS No.

957135-43-2

SM-164

SM-164 is a potent cell-permeable and bivalent Smac mimetic which bind to a XIAP protein with a Ki value of 0.56 nM, and binds to cIAP-1 and cIAP-2 proteins with Ki values of 0.31 and 1.1 nM, respectively.

Cat. No.

A12738

CAS No.

1260251-31-7

Birinapant (TL32711)

Synonyms: TL-32711

Birinapant, also known as TL32711, is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity.

Cat. No.

A14135

CAS No.

873652-48-3

GDC-0152

GDC-0152 is a second mitochondrial activator of caspases (Smac) mimetic inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity.

Cat. No.

A16996

CAS No.

1799328-86-1

Tolinapant (ASTX-660)

Synonyms: ASTX660

ASTX660 is an orally bioavailable, non-peptidomimetic antagonist of both X chromosome-linked inhibitor of apoptosis protein (XIAP) and cellular IAP 1 (cIAP1), with potential antineoplastic and pro-apoptoticctivities. 1799328-86-1 (free base) 1799328-50-9 (HCl) 1799328-90-7 (mesylate) 1799328-88-3 (sulfate)

Cat. No.

A18963

CAS No.

1001600-54-9

MV1

MV1 is an antagonist of IAP (inhibitor of apoptosis protein), leads to protein knockdown of HaloTag-fused proteins when combined with HaloTag ligand.

Cat. No.

A20943

CAS No.

1446182-94-0

CUDC-427

Synonyms: GDC-0917

CUDC-427 is a potent second-generation pan-selective IAP antagonist, used for treatment of various cancers.

Cat. No.

A21735

CAS No.

1258392-53-8

AZD5582

AZD5582 is an antagonist of the inhibitor of apoptosis proteins (IAPs), which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively.

Cat. No.

A30797

CAS No.

1883545-51-4

AZD5582 dihydrochloride

AZD5582 dihydrochloride is a selective antagonist of inhibitor of apoptosis proteins (IAPs), effectively targeting the BIR3 domains of cIAP1, cIAP2, and XIAP with IC50 values of 15, 21, and 15 nM, respectively. This compound induces apoptosis in various tumor cell types, making it a valuable tool for cancer research. AZD5582 is utilized in studies focused on therapeutic strategies that exploit the apoptotic pathway to enhance treatment efficacy.