IAP

Cat. No.

A11163

CAS No.

1071992-99-8

Xevinapant (AT-406, SM-406, ARRY-334543)

Synonyms: AT406; SM-406; ARRY-334543

AT-406 is an orally bioavailable inhibitor of IAP family of proteins with potential apoptotic inducing and antineoplastic activity. AT-406 selectively inhibits the biological activity of IAP proteins, including X chromosome-linked IAP (XIAP), the cellular IAPs 1 (c-IAP1) and 2 (c-IAP2) and melanoma inhibitor of apoptosis protein (ML-IAP).

Cat. No.

A14231

CAS No.

1001600-56-1

BV-6

BV-6 is a SMAC mimetic, dual cIAP and XIAP inhibitor.

Cat. No.

A13055

CAS No.

550-24-3

Embelin

Synonyms: Embelic acid; Emberine; NSC 91874

Embelin is a cell-permeable benzoquinone compound that exhibits antitumor properties.

Cat. No.

A13058

CAS No.

54135-60-3

M50054

Apoptosis Inhibitor is a cell-permeable inhibitor of apoptosis induction.

Cat. No.

A22626

CAS No.

151636-76-9

(R)-FL118

Synonyms: FL 118,FL-118

FL118 is an inhibitor of human survivin expression, activating tumor suppressor p53 as a novel MOA in p53 wild-type cancer cells.

Cat. No.

A25424

CAS No.

85698-31-3

Sanggenon G

Sanggenon G is a potent inhibitor of the X-linked inhibitor of apoptosis protein (XIAP), targeting the BIR3 domain with a binding affinity of 34.26 μM. This cell-permeable compound enhances caspase activation, facilitating apoptosis in various cell models. Sanggenon G is useful for research applications focused on cell death mechanisms and potential therapeutic development for conditions associated with apoptosis dysregulation.

Cat. No.

A30364

CAS No.

1570231-89-8

Dasminapant

Synonyms: APG-1387

Dasminapant is a bivalent SMAC mimetic that functions as an inhibitor of inhibitor of apoptosis proteins (IAPs), specifically targeting XIAP, cIAP-1, cIAP-2, and ML-IAP. This compound induces the degradation of cIAP-1 and XIAP, resulting in the activation of caspase-3 and subsequent PARP cleavage, ultimately leading to programmed cell death (apoptosis). Dasminapant is valuable in research applications concerning hepatocellular carcinoma, ovarian cancer, and nasopharyngeal carcinoma, providing insights into novel therapeutic strategies.

Cat. No.

A30834

CAS No.

1562375-46-5

SM-1295

SM-1295 is an inhibitor of apoptosis protein (IAP) antagonist that selectively inhibits XIAP-BIR3, c-IAP1-BIR3, and c-IAP2-BIR3, with Kd values of 3077 nM, 3.2 nM, and 9.5 nM, respectively. This compound disrupts IAP-mediated cellular survival signals, promoting apoptosis in cancer cells. SM-1295 is a valuable tool for research in cancer therapy, apoptosis signaling, and the study of IAP functions in various biological contexts.

Cat. No.

A33695

CAS No.

867324-12-7

LBW242

LBW242 is a potent inhibitor of Inhibitor of Apoptosis Proteins (IAPs) that functions as a Smac mimetic. This compound demonstrates pro-apoptotic activity and is particularly effective in mutant FLT3-expressing cells. LBW242 has been shown to enhance the cytotoxic effects of TRAIL and other anticancer agents on ovarian cancer cells, making it a valuable reagent for research in multiple myeloma and other cancer therapies.

Cat. No.

A53778

CAS No.

847137-53-5

CST530

CST530 is an inhibitor of apoptosis protein (IAP) antagonist that targets the BIR3 domain of IAP. By disrupting IAP function, CST530 facilitates the ubiquitination and subsequent degradation of cIAP1. This reagent is suitable for research applications involving protein degradation strategies, including the development of PROTACs, to explore the regulation of apoptotic pathways.

Cat. No.

A53780

CAS No.

2941243-62-3

Anticancer agent 128

Anticancer agent 128 is an IAP (Inhibitor of Apoptosis Protein) inhibitor that covalently targets the BIR3 domains of XIAP, cIAP1, and cIAP2. This compound exhibits potent biological activity, with IC50 values of 24.9 nM, 19.3 nM, and 10.3 nM against these targets, respectively. It is pivotal for research applications involving apoptosis regulation and cancer treatment strategies, offering a promising avenue for therapeutic development.

Cat. No.

A53781

CAS No.

1363145-46-3

HM90822

HM90822 is an orally active inhibitor of Inhibitor of Apoptosis Proteins (IAPs). It promotes the ubiquitination and subsequent proteasomal degradation of XIAP, cIAP1, and cIAP2, leading to apoptotic cell death in sensitive pancreatic cancer cell lines. Additionally, HM90822 demonstrates significant tumor growth inhibition in Panc-1 pancreatic cancer xenograft and orthotopic mouse models. This reagent is a valuable tool for investigating mechanisms of pancreatic cancer and potential therapeutic strategies.

Cat. No.

A53782

CAS No.

2410953-19-2

Anticancer agent 127

Anticancer Agent 127 is a potent inhibitor of inhibitor of apoptosis proteins (IAPs), specifically covalently targeting the BIR3 domains of XIAP, cIAP1, and cIAP2. With IC50 values of 12 nM, 14 nM, and 9 nM for each respective target, it effectively disrupts the anti-apoptotic functions of these proteins. This compound demonstrates significant anticancer activity and is valuable for research applications focused on apoptosis regulation and cancer biology.

Cat. No.

A53793

CAS No.

949963-04-6

AEG40826

Synonyms: HGS1029

AEG40826 is a potent inhibitor of apoptosis (IAP) that functions as a second mitochondria-derived activator of caspases (SMAC) mimetic. It effectively degrades cellular inhibitor of apoptosis protein 1 (cIAP1) and interferes with tumor necrosis factor alpha (TNF-α) pro-survival signaling pathways. AEG40826 is widely utilized in cancer research, particularly in studies exploring apoptosis modulation and therapeutic resistance mechanisms.