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Assay Controls & Cell Stimulation

Assay controls and cell stimulation reagents give defined responses that anchor cell-based experiments. Phorbol 12-myristate 13-acetate (PMA) with ionomycin activates T cells, and brefeldin A or monensin retain cytokines for intracellular staining. Staurosporine induces apoptosis, which the pan-caspase inhibitor Z-VAD-FMK blocks, while erastin and RSL3 trigger ferroptosis and ferrostatin-1 prevents it. Mitochondrial stress tests combine oligomycin, FCCP and rotenone, and tunicamycin induces endoplasmic reticulum stress. Bafilomycin A1 and chloroquine block autophagic flux at the lysosome, a standard control in autophagy assays. Nocodazole, thymidine and RO-3306 arrest cells at defined cell cycle stages for synchronization.

Items 26-28 of 28

  • Necrostatin-1 (inactive control)
    Cat. No.
    A53920
    CAS No.
    64419-92-7

    Necrostatin-1 (inactive control)

    Synonyms: Nec-1 (inactive control)

    Necrostatin-1 (inactive control) is an inactive analog of the potent necroptosis inhibitor Necrostatin-1. This compound serves as a negative control in research studies involving necroptosis mechanisms, allowing for the differentiation between specific and non-specific effects in cellular assays. It is crucial for validating experimental results and ensuring the reliability of data related to necroptosis and cell death pathways.

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    1 mg
    $65.00
    5 mg
    $210.00
    All 4 sizes
  • Palbociclib hydrochloride
    Cat. No.
    A54125
    CAS No.
    571189-11-2

    Palbociclib hydrochloride

    Synonyms: PD-0332991 hydrochloride

    Palbociclib hydrochloride is a selective inhibitor of cyclin-dependent kinases CDK4 and CDK6, with IC50 values of 11 nM and 16 nM, respectively. This compound demonstrates significant anti-proliferative activity, effectively inducing cell cycle arrest in malignant cells. Palbociclib hydrochloride is utilized in research focused on HR-positive and HER2-negative breast cancer as well as hepatocellular carcinoma, making it a valuable tool for understanding tumor biology and therapeutic responses.

    In stock View Details
    2 mg
    $25.00
    5 mg
    $40.00
    All 9 sizes
  • Palbociclib dihydrochloride
    Cat. No.
    A54271
    CAS No.
    1831842-69-3

    Palbociclib dihydrochloride

    Synonyms: PD-0332991 dihydrochloride

    Palbociclib dihydrochloride is a selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6) with IC50 values of 11 nM and 16 nM, respectively. This compound exhibits significant anti-proliferative effects and induces cell cycle arrest in various cancer cell lines. It is particularly relevant for research applications in hormone receptor-positive and HER2-negative breast cancer, as well as hepatocellular carcinoma, providing insights into tumor growth regulation and potential therapeutic strategies.

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    Out of stock

    All 3 sizes

Items 26-28 of 28

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